InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Nek6

Summary

InnateDB Gene

IDBG-166676.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nek6

Gene Name

NIMA (never in mitosis gene a)-related expressed kinase 6

Synonyms

1300007C09Rik

Species

Mus musculus

Ensembl Gene

ENSMUSG00000026749

Encoded Proteins

IDBP-166678

NIMA (never in mitosis gene a)-related expressed kinase 6

IDBP-255004

NIMA (never in mitosis gene a)-related expressed kinase 6

IDBP-255006

NIMA (never in mitosis gene a)-related expressed kinase 6

IDBP-539244

NIMA (never in mitosis gene a)-related expressed kinase 6

IDBP-541163

NIMA (never in mitosis gene a)-related expressed kinase 6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000119408:
The protein encoded by this gene is a kinase required for progression through the metaphase portion of mitosis. Inhibition of the encoded protein can lead to apoptosis. This protein also can enhance tumorigenesis by suppressing tumor cell senescence. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:38511643-38588041

Strand

Forward strand

Band

Transcripts

ENSMUST00000054234	ENSMUSP00000049723
ENSMUST00000112902	ENSMUSP00000108523
ENSMUST00000112895	ENSMUSP00000108516
ENSMUST00000151683	ENSMUSP00000120294
ENSMUST00000156726	ENSMUSP00000114376

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 47 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	47 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019894	kinesin binding
GO:0019901	protein kinase binding

Biological Process

GO:0006468	protein phosphorylation
GO:0006915	apoptotic process
GO:0007059	chromosome segregation
GO:0007067	mitotic nuclear division
GO:0007165	signal transduction
GO:0018105	peptidyl-serine phosphorylation
GO:0030071	regulation of mitotic metaphase/anaphase transition
GO:0031572	G2 DNA damage checkpoint
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0046777	protein autophosphorylation