InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gnao1

Summary

InnateDB Protein

IDBP-541205.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gnao1

Protein Name

guanine nucleotide binding protein, alpha O

Synonyms

alphaO; AW050213; Galphao; Gnao;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000114144

InnateDB Gene

IDBG-181138 (Gnao1)

Protein Structure

UniProt Annotation

Function

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Stimulated by RGS14. The G(o) protein function is not clear. {ECO:0000269PubMed:10926822}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:15585744}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0019001	guanyl nucleotide binding
GO:0031683	G-protein beta/gamma-subunit complex binding
GO:0031821	G-protein coupled serotonin receptor binding
GO:0031852	mu-type opioid receptor binding
GO:0032403	protein complex binding
GO:0032794	GTPase activating protein binding
GO:0046872	metal ion binding
GO:0051430	corticotropin-releasing hormone receptor 1 binding

Biological Process

GO:0006184	GTP catabolic process
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007212	dopamine receptor signaling pathway
GO:0007568	aging
GO:0007626	locomotory behavior
GO:0008016	regulation of heart contraction
GO:0009987	cellular process
GO:0010243	response to organonitrogen compound
GO:0014070	response to organic cyclic compound
GO:0030900	forebrain development
GO:0031175	neuron projection development
GO:0034097	response to cytokine
GO:0042493	response to drug
GO:0042542	response to hydrogen peroxide
GO:0043278	response to morphine
GO:0043547	positive regulation of GTPase activity
GO:0051926	negative regulation of calcium ion transport

Cellular Component

GO:0005622	intracellular
GO:0005834	heterotrimeric G-protein complex
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
GO:0043005	neuron projection
GO:0043234	protein complex

Protein Structure and Domains

PDB ID

MGI:95775

InterPro

IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit
IPR001408 G-protein alpha subunit, group I
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR011025 G protein alpha subunit, helical insertion
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00503
PF00025

PRINTS

PR00318
PR00441
PR00328

PIRSF

SMART

SM00275

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt