InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Irak3

Summary

InnateDB Protein

IDBP-541209.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Irak3

Protein Name

interleukin-1 receptor-associated kinase 3

Synonyms

4833428C18Rik; AI563835; IRAK-M;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000123604

InnateDB Gene

IDBG-192499 (Irak3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	25 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0006915	apoptotic process
GO:0007165	signal transduction
GO:0042981	regulation of apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0046777	protein autophosphorylation
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0070498	interleukin-1-mediated signaling pathway

Cellular Component

Protein Structure and Domains

PDB ID

MGI:1921164

InterPro

IPR000488 Death domain
IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR011009 Protein kinase-like domain
IPR011029 Death-like domain

PFAM

PF00531
PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00005

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

D6RCU1

UniProt Splice Variant

Entrez Gene

73914

UniGene

Mm.146194

RefSeq

MGI ID

MGI Symbol

Irak3

OMIM

CCDS

HPRD

IMGT

EMBL

AC144942

GenPept