InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cd46

Summary

InnateDB Protein

IDBP-541232.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cd46

Protein Name

CD46 antigen, complement regulatory protein

Synonyms

Mcp;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000123931

InnateDB Gene

IDBG-209330 (Cd46)

Protein Structure

UniProt Annotation

Function

May be involved in the fusion of the spermatozoa with the oocyte during fertilization. {ECO:0000269PubMed:12640142}.

Subcellular Localization

Isoform 1: Cytoplasmic vesicle, secretory vesicle, acrosome inner membrane; Single-pass type I membrane protein. Note=Inner acrosomal membrane of spermatozoa.Isoform 2: Secreted {ECO:0000305}.

Disease Associations

Tissue Specificity

Present only in testis (at protein level). {ECO:0000269PubMed:12640142, ECO:0000269PubMed:9461505, ECO:0000269PubMed:9799332}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001848	complement binding

Biological Process

GO:0006508	proteolysis
GO:0007338	single fertilization
GO:0045087	innate immune response (InnateDB)
GO:0045916	negative regulation of complement activation

Cellular Component

GO:0002079	inner acrosomal membrane
GO:0005576	extracellular region
GO:0005794	Golgi apparatus
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane