InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Elp4

Summary

InnateDB Protein

IDBP-541325.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Elp4

Protein Name

elongation protein 4 homolog (S. cerevisiae)

Synonyms

A330107A17Rik; Paxneb;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000116575

InnateDB Gene

IDBG-195192 (Elp4)

Protein Structure

UniProt Annotation

Function

Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4 (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004402	histone acetyltransferase activity
GO:0008607	phosphorylase kinase regulator activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0016573	histone acetylation
GO:0045859	regulation of protein kinase activity

Cellular Component

GO:0005737	cytoplasm
GO:0008023	transcription elongation factor complex
GO:0016591	DNA-directed RNA polymerase II, holoenzyme
GO:0033588	Elongator holoenzyme complex