Version 5.4
| Mus musculus Protein: Tle2 | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-541514.3 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Tle2 | ||||||||
| Protein Name | transducin-like enhancer of split 2, homolog of Drosophila E(spl) | ||||||||
| Synonyms | Grg2; mKIAA4188; | ||||||||
| Species | Mus musculus | ||||||||
| Ensembl Protein | ENSMUSP00000121125 | ||||||||
| InnateDB Gene | IDBG-178883 (Tle2) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity). {ECO:0000250}. | ||||||||
| Subcellular Localization | Nucleus. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | |||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | MGI:104635 | ||||||||
| InterPro |
IPR001680
WD40 repeat IPR005617 Groucho/TLE, N-terminal Q-rich domain IPR009146 Groucho/transducin-like enhancer IPR017986 WD40-repeat-containing domain |
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| PFAM |
PF00400
PF03920 |
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| PRINTS |
PR01850
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| PIRSF | |||||||||
| SMART |
SM00320
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| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | Q9WVB2 | ||||||||
| PhosphoSite | PhosphoSite-Q9WVB2 | ||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 21886 | ||||||||
| UniGene | Mm.488654 | ||||||||
| RefSeq | NP_062699 | ||||||||
| MGI ID | |||||||||
| MGI Symbol | Tle2 | ||||||||
| OMIM | |||||||||
| CCDS | CCDS24063 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AF145958 | ||||||||
| GenPept | AAD37694 | ||||||||