Version 5.4
| Mus musculus Gene: Tle2 | |||||||||||
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| Summary | |||||||||||
| InnateDB Gene | IDBG-178883.6 | ||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||
| Gene Symbol | Tle2 | ||||||||||
| Gene Name | transducin-like enhancer of split 2, homolog of Drosophila E(spl) | ||||||||||
| Synonyms | Grg2; mKIAA4188 | ||||||||||
| Species | Mus musculus | ||||||||||
| Ensembl Gene | ENSMUSG00000034771 | ||||||||||
| Encoded Proteins |
transducin-like enhancer of split 2, homolog of Drosophila E(spl)
transducin-like enhancer of split 2, homolog of Drosophila E(spl)
transducin-like enhancer of split 2, homolog of Drosophila E(spl)
transducin-like enhancer of split 2, homolog of Drosophila E(spl)
transducin-like enhancer of split 2, homolog of Drosophila E(spl)
transducin-like enhancer of split 2, homolog of Drosophila E(spl)
transducin-like enhancer of split 2, homolog of Drosophila E(spl)
transducin-like enhancer of split 2, homolog of Drosophila E(spl)
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||
| Entrez Gene | |||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000065717:
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| Gene Information | |||||||||||
| Type | Protein coding | ||||||||||
| Genomic Location | Chromosome 10:81574561-81590845 | ||||||||||
| Strand | Forward strand | ||||||||||
| Band | C1 | ||||||||||
| Transcripts | |||||||||||
| Interactions | |||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||
| NETPATH | |||||||||||
| REACTOME |
Disease pathway
deletions in the AMER1 gene destabilize the destruction complex pathway
Signaling by Wnt pathway
Signaling by WNT in cancer pathway
Degradation of beta-catenin by the destruction complex pathway
repression of WNT target genes pathway
AMER1 mutants destabilize the destruction complex pathway
AXIN mutants destabilize the destruction complex, activating WNT signaling pathway
T41 mutants of beta-catenin aren't phosphorylated pathway
deactivation of the beta-catenin transactivating complex pathway
formation of the beta-catenin:TCF transactivating complex pathway
APC truncation mutants have impaired AXIN binding pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex pathway
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling pathway
Signaling by NOTCH1 pathway
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
S37 mutants of beta-catenin aren't phosphorylated pathway
AXIN missense mutants destabilize the destruction complex pathway
TCF dependent signaling in response to WNT pathway
Signaling by NOTCH1 in Cancer pathway
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
FBXW7 Mutants and NOTCH1 in Cancer pathway
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
APC truncation mutants are not K63 polyubiquitinated pathway
S45 mutants of beta-catenin aren't phosphorylated pathway
misspliced GSK3beta mutants stabilize beta-catenin pathway
TCF7L2 mutants don't bind CTBP pathway
truncations of AMER1 destabilize the destruction complex pathway
NOTCH1 Intracellular Domain Regulates Transcription pathway
Signal Transduction pathway
truncated APC mutants destabilize the destruction complex pathway
Signaling by NOTCH pathway
S33 mutants of beta-catenin aren't phosphorylated pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
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| KEGG | |||||||||||
| INOH |
Wnt signaling pathway pathway
TGF-beta signaling pathway
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| PID NCI | |||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||
| NETPATH | |||||||||||
| REACTOME |
NOTCH1 Intracellular Domain Regulates Transcription pathway
Degradation of beta-catenin by the destruction complex pathway
truncated APC mutants destabilize the destruction complex pathway
AXIN mutants destabilize the destruction complex, activating WNT signaling pathway
APC truncation mutants are not K63 polyubiquitinated pathway
AMER1 mutants destabilize the destruction complex pathway
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
Signaling by WNT in cancer pathway
AXIN missense mutants destabilize the destruction complex pathway
Signaling by Wnt pathway
Signaling by NOTCH1 in Cancer pathway
APC truncation mutants have impaired AXIN binding pathway
deactivation of the beta-catenin transactivating complex pathway
T41 mutants of beta-catenin aren't phosphorylated pathway
FBXW7 Mutants and NOTCH1 in Cancer pathway
Signal Transduction pathway
misspliced GSK3beta mutants stabilize beta-catenin pathway
S45 mutants of beta-catenin aren't phosphorylated pathway
deletions in the AMER1 gene destabilize the destruction complex pathway
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
S33 mutants of beta-catenin aren't phosphorylated pathway
truncations of AMER1 destabilize the destruction complex pathway
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex pathway
TCF dependent signaling in response to WNT pathway
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
Signaling by NOTCH pathway
repression of WNT target genes pathway
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling pathway
Signaling by NOTCH1 pathway
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
TCF7L2 mutants don't bind CTBP pathway
formation of the beta-catenin:TCF transactivating complex pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
S37 mutants of beta-catenin aren't phosphorylated pathway
Disease pathway
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| KEGG | |||||||||||
| INOH |
Wnt signaling pathway pathway
TGF-beta signaling pathway
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| PID NCI |
Regulation of nuclear beta catenin signaling and target gene transcription
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| Cross-References | |||||||||||
| SwissProt | Q9WVB2 | ||||||||||
| TrEMBL | D3Z1A4 D3Z2J7 E9PV07 Q3UN01 Q6IR16 | ||||||||||
| UniProt Splice Variant | |||||||||||
| Entrez Gene | 21886 | ||||||||||
| UniGene | Mm.488654 | ||||||||||
| RefSeq | NM_001252401 NM_019725 XM_006513584 | ||||||||||
| OMIM | |||||||||||
| CCDS | CCDS24063 CCDS56737 | ||||||||||
| HPRD | |||||||||||
| IMGT | |||||||||||
| MGI ID | MGI:104635 | ||||||||||
| MGI Symbol | Tle2 | ||||||||||
| EMBL | AC153919 AC159474 AF145958 AK144581 BC071219 | ||||||||||
| GenPept | AAD37694 AAH71219 BAE25947 | ||||||||||
| RNA Seq Atlas | 21886 | ||||||||||