Version 5.4
Mus musculus Protein: Prdm9
Summary
InnateDB Protein IDBP-541740.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Prdm9
Protein Name PR domain containing 9
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000118454
InnateDB Gene IDBG-140068 (Prdm9)
Protein Structure
UniProt Annotation
Function Histone methyltransferase that specifically trimethylates 'Lys-4' of histone H3 during meiotic prophase and is essential for proper meiotic progression. Does not have the ability to mono- and dimethylate 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes during early meiotic prophase. {ECO:0000269PubMed:16292313}.
Subcellular Localization Nucleus {ECO:0000305}. Chromosome {ECO:0000305}.
Disease Associations
Tissue Specificity Specifically expressed in germ cells entering meiotic prophase in female fetal gonads and in postnatal testis. {ECO:0000269PubMed:16292313}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0010844 recombination hotspot binding
GO:0042800 histone methyltransferase activity (H3-K4 specific)
GO:0043565 sequence-specific DNA binding
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007126 meiotic nuclear division
GO:0007283 spermatogenesis
GO:0010845 positive regulation of reciprocal meiotic recombination
GO:0016571 histone methylation
GO:0034968 histone lysine methylation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051568 histone H3-K4 methylation
GO:0060903 positive regulation of meiosis I
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
Protein Structure and Domains
PDB ID MGI:2384854
InterPro IPR001214 SET domain
IPR019041 SSXRD motif
PFAM PF00856
PF09514
PRINTS
PIRSF
SMART SM00317
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96EQ9
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 213389
UniGene Mm.215162
RefSeq
MGI ID 4C1Q
MGI Symbol Prdm9
OMIM
CCDS
HPRD
IMGT
EMBL AC154378 AY294423 BC012016 BC049903 CT033750
GenPept AAH12016 AAH49903 AAQ01511 CAX15894

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca