InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dnm1

Summary

InnateDB Protein

IDBP-541788.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dnm1

Protein Name

dynamin 1

Synonyms

AI838169; Dnm; Ftfl; mKIAA4093;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000122679

InnateDB Gene

IDBG-159551 (Dnm1)

Protein Structure

UniProt Annotation

Function

Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:11082044}. Cytoplasm, cytoskeleton {ECO:0000269PubMed:11082044}. Note=Microtubule-associated.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 45 interaction(s) predicted by orthology.

Experimentally validated
Total	31 [view]
Protein-Protein	31 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	45 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0008022	protein C-terminus binding
GO:0019901	protein kinase binding
GO:0032403	protein complex binding
GO:0042802	identical protein binding

Biological Process

GO:0006184	GTP catabolic process
GO:0007032	endosome organization
GO:0031623	receptor internalization

Cellular Component

GO:0005874	microtubule
GO:0030117	membrane coat

Protein Structure and Domains

PDB ID

MGI:107384

InterPro

IPR000375 Dynamin central domain
IPR001401 Dynamin, GTPase domain
IPR001849 Pleckstrin homology domain
IPR003130 Dynamin GTPase effector
IPR022812 Dynamin superfamily
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF01031
PF00350
PF00169
PF02212

PRINTS

PR00195

PIRSF

SMART

SM00053
SM00233
SM00302

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt