Version 5.4
Mus musculus Gene: Dnm1
Summary
InnateDB Gene IDBG-159551.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dnm1
Gene Name dynamin 1
Synonyms AI838169; Dnm; Ftfl; mKIAA4093
Species Mus musculus
Ensembl Gene ENSMUSG00000026825
Encoded Proteins
IDBP-159553
dynamin 1
IDBP-159559
dynamin 1
IDBP-254023
dynamin 1
IDBP-254029
dynamin 1
IDBP-254031
dynamin 1
IDBP-541788
dynamin 1
IDBP-540853
dynamin 1
IDBP-532188
dynamin 1
IDBP-537474
dynamin 1
IDBP-536583
dynamin 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the dynamin subfamily of GTP-binding proteins. The encoded protein is a GTPase which is required for membrane recycling, including vesicle endocytosis in neurons. It may also be involved in cellular fission via association with microtubules and actin filaments. Mutations in this gene have been shown to cause seizures. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:32308471-32353329
Strand Reverse strand
Band B
Transcripts
ENSMUST00000091089 ENSMUSP00000088618
ENSMUST00000078352 ENSMUSP00000077461
ENSMUST00000113365 ENSMUSP00000108992
ENSMUST00000113352 ENSMUSP00000108979
ENSMUST00000113350 ENSMUSP00000108977
ENSMUST00000139624 ENSMUSP00000122679
ENSMUST00000129156 ENSMUSP00000118914
ENSMUST00000145885
ENSMUST00000155269 ENSMUSP00000116054
ENSMUST00000139291 ENSMUSP00000115523
ENSMUST00000156866
ENSMUST00000141633
ENSMUST00000139238 ENSMUSP00000118855
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 45 interaction(s) predicted by orthology.
Experimentally validated
Total 31 [view]
Protein-Protein 31 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 45 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0008022 protein C-terminus binding
GO:0019901 protein kinase binding
GO:0032403 protein complex binding
GO:0042802 identical protein binding
GO:0044822 poly(A) RNA binding
GO:0050998 nitric-oxide synthase binding
Biological Process
GO:0006184 GTP catabolic process
GO:0006897 endocytosis
GO:0006898 receptor-mediated endocytosis
GO:0007032 endosome organization
GO:0031623 receptor internalization
Cellular Component
GO:0005874 microtubule
GO:0030117 membrane coat
GO:0043234 protein complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000106976
View Gene Order
ENSBTAG00000011307
Not yet available
Pathways
NETPATH
REACTOME
REACT_239142
Innate Immune System pathway
REACT_224389
Gap junction trafficking and regulation pathway
REACT_257923
Recycling pathway of L1 pathway
REACT_209837
Membrane Trafficking pathway
REACT_220352
Formation of annular gap junctions pathway
REACT_230745
Immune System pathway
REACT_202778
Retrograde neurotrophin signalling pathway
REACT_196550
MHC class II antigen presentation pathway
REACT_209040
Gap junction degradation pathway
REACT_261444
Axon guidance pathway
REACT_251547
Toll-Like Receptors Cascades pathway
REACT_219680
L1CAM interactions pathway
REACT_248921
Signalling by NGF pathway
REACT_229531
Adaptive Immune System pathway
REACT_188576
Developmental Biology pathway
REACT_237883
NGF signalling via TRKA from the plasma membrane pathway
REACT_217189
Gap junction trafficking pathway
REACT_188257
Signal Transduction pathway
REACT_246719
Toll Like Receptor 4 (TLR4) Cascade pathway
KEGG
mmu04144
Endocytosis pathway
mmu05100
Bacterial invasion of epithelial cells pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
NetPath_15
IL3 pathway
REACTOME
REACT_6894
Toll Like Receptor 4 (TLR4) Cascade pathway
REACT_121399
MHC class II antigen presentation pathway
REACT_12435
Retrograde neurotrophin signalling pathway
REACT_11049
Formation of annular gap junctions pathway
REACT_11035
Gap junction degradation pathway
REACT_22365
Recycling pathway of L1 pathway
REACT_22205
L1CAM interactions pathway
REACT_111045
Developmental Biology pathway
REACT_11061
Signalling by NGF pathway
REACT_6802
Innate Immune System pathway
REACT_6966
Toll-Like Receptors Cascades pathway
REACT_18266
Axon guidance pathway
REACT_111102
Signal Transduction pathway
REACT_9411
Gap junction trafficking pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_228189
EPH-ephrin mediated repulsion of cells pathway
REACT_228170
EPH-Ephrin signaling pathway
REACT_9480
Gap junction trafficking and regulation pathway
REACT_11123
Membrane Trafficking pathway
REACT_223433
Recycling pathway of L1 pathway
REACT_202205
Retrograde neurotrophin signalling pathway
REACT_215526
L1CAM interactions pathway
REACT_213138
Immune System pathway
REACT_203998
Gap junction trafficking pathway
REACT_219220
Toll-Like Receptors Cascades pathway
REACT_214353
Signal Transduction pathway
REACT_202965
Formation of annular gap junctions pathway
REACT_203140
Axon guidance pathway
REACT_211133
MHC class II antigen presentation pathway
REACT_224535
Gap junction trafficking and regulation pathway
REACT_207949
NGF signalling via TRKA from the plasma membrane pathway
REACT_207066
Signalling by NGF pathway
REACT_214469
Adaptive Immune System pathway
REACT_216714
Innate Immune System pathway
REACT_207353
Gap junction degradation pathway
REACT_211704
Toll Like Receptor 4 (TLR4) Cascade pathway
REACT_220844
Developmental Biology pathway
REACT_213260
Membrane Trafficking pathway
KEGG
hsa04144
Endocytosis pathway
hsa05100
Bacterial invasion of epithelial cells pathway
INOH
PID NCI
txa2pathway
Thromboxane A2 receptor signaling
il8cxcr2_pathway
IL8- and CXCR2-mediated signaling events
cxcr4_pathway
CXCR4-mediated signaling events
il8cxcr1_pathway
IL8- and CXCR1-mediated signaling events
erbb1_internalization_pathway
Internalization of ErbB1
ephbfwdpathway
EPHB forward signaling
trkrpathway
Neurotrophic factor-mediated Trk receptor signaling
ephrinbrevpathway
Ephrin B reverse signaling
cxcr3pathway
CXCR3-mediated signaling events
notch_pathway
Notch signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.44736
RefSeq NM_010065 XM_006497650 XM_006497651 XM_006497652 XM_006497653 XM_006497654 XM_006497655 XM_006497656 XM_006497657 XM_006497658 XM_006497659 XM_006497661
OMIM
CCDS CCDS38102
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca