InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ocln

Summary

InnateDB Protein

IDBP-541796.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ocln

Protein Name

occludin

Synonyms

AI503564; Ocl;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000124849

InnateDB Gene

IDBG-178074 (Ocln)

Protein Structure

UniProt Annotation

Function

May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier.

Subcellular Localization

Membrane; Multi-pass membrane protein. Cell junction, tight junction.

Disease Associations

Tissue Specificity

Localized at tight junctions of both epithelial and endothelial cells. Highly expressed in the testis, kidney, lung, liver and brain. Not detected in skeletal muscle, spleen and heart.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005198	structural molecule activity
GO:0005515	protein binding
GO:0008119	thiopurine S-methyltransferase activity

Biological Process

GO:0032259	methylation
GO:0045216	cell-cell junction organization
GO:0046498	S-adenosylhomocysteine metabolic process
GO:0046500	S-adenosylmethionine metabolic process

Cellular Component

GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0005923	tight junction
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0016327	apicolateral plasma membrane
GO:0030139	endocytic vesicle