Version 5.4
Homo sapiens Protein: TDG
Summary
InnateDB Protein IDBP-54195.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TDG
Protein Name thymine-DNA glycosylase
Synonyms hTDG;
Species Homo sapiens
Ensembl Protein ENSP00000266775
InnateDB Gene IDBG-54193 (TDG)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 45 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 45 [view]
Protein-Protein 44 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds
GO:0030983 mismatched DNA binding
Biological Process
GO:0006281 DNA repair
GO:0006298 mismatch repair
Cellular Component
GO:0005634 nucleus
GO:0005886 plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR003310 Thymine-DNA glycosylase
IPR005122 Uracil-DNA glycosylase-like
PFAM PF03167
PRINTS
PIRSF
SMART SM00986
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL G8JL98
UniProt Splice Variant
Entrez Gene 6996
UniGene Hs.707510
RefSeq
HUGO HGNC:11700
OMIM 601423
CCDS
HPRD 03251
IMGT
EMBL AC078819 AK303631
GenPept BAG64639

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca