InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TDG

Summary

InnateDB Gene

IDBG-54193.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TDG

Gene Name

thymine-DNA glycosylase

Synonyms

hTDG

Species

Homo sapiens

Ensembl Gene

ENSG00000139372

Encoded Proteins

IDBP-54195

thymine-DNA glycosylase

IDBP-244771

thymine-DNA glycosylase

IDBP-382203

thymine-DNA glycosylase

IDBP-586625

thymine-DNA glycosylase

IDBP-597866

thymine-DNA glycosylase

IDBP-595512

thymine-DNA glycosylase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:103965804-103988874

Strand

Forward strand

Band

q23.3

Transcripts

ENST00000266775	ENSP00000266775
ENST00000392872	ENSP00000376611
ENST00000436021	ENSP00000390167
ENST00000545698
ENST00000544861	ENSP00000445899
ENST00000537100	ENSP00000439825
ENST00000544060
ENST00000542926
ENST00000540956	ENSP00000445716
ENST00000536395

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 45 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	45 [view]
Protein-Protein	44 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001104	RNA polymerase II transcription cofactor activity
GO:0003684	damaged DNA binding
GO:0003690	double-stranded DNA binding
GO:0005080	protein kinase C binding
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0008263	pyrimidine-specific mismatch base pair DNA N-glycosylase activity
GO:0016798	hydrolase activity, acting on glycosyl bonds
GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds
GO:0019104	DNA N-glycosylase activity
GO:0019904	protein domain specific binding
GO:0030983	mismatched DNA binding
GO:0032183	SUMO binding
GO:0042803	protein homodimerization activity
GO:0043566	structure-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006281	DNA repair
GO:0006284	base-excision repair
GO:0006285	base-excision repair, AP site formation
GO:0006298	mismatch repair
GO:0006366	transcription from RNA polymerase II promoter
GO:0009790	embryo development
GO:0016568	chromatin modification
GO:0032091	negative regulation of protein binding
GO:0035562	negative regulation of chromatin binding
GO:0040029	regulation of gene expression, epigenetic
GO:0045008	depyrimidination
GO:0080111	DNA demethylation