InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rasgrp4

Summary

InnateDB Protein

IDBP-541978.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rasgrp4

Protein Name

RAS guanyl releasing protein 4

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000124183

InnateDB Gene

IDBG-165997 (Rasgrp4)

Protein Structure

UniProt Annotation

Function

Functions as a cation- and diacylglycerol (DAG)- regulated nucleotide exchange factor activating Ras through the exchange of bound GDP for GTP. May function in mast cells differentiation. {ECO:0000269PubMed:12817022}.

Subcellular Localization

Cytoplasm. Cell membrane. Note=Recruited to membranes upon activation by DAG.

Disease Associations

Tissue Specificity

Expressed by mast cells and their progenitors (at protein level). {ECO:0000269PubMed:11956218, ECO:0000269PubMed:12817022}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005088	Ras guanyl-nucleotide exchange factor activity
GO:0046872	metal ion binding

Biological Process

GO:0007264	small GTPase mediated signal transduction
GO:0008283	cell proliferation
GO:0009991	response to extracellular stimulus
GO:0016049	cell growth
GO:0030154	cell differentiation
GO:0032318	regulation of Ras GTPase activity
GO:0035556	intracellular signal transduction
GO:0046579	positive regulation of Ras protein signal transduction
GO:0051056	regulation of small GTPase mediated signal transduction

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0016020	membrane

Protein Structure and Domains

PDB ID

MGI:2386851

InterPro

IPR000651 Ras-like guanine nucleotide exchange factor, N-terminal
IPR001895 Guanine-nucleotide dissociation stimulator CDC25
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
IPR023578 Ras guanine nucleotide exchange factor, domain

PFAM

PF00618
PF00617
PF00130

PRINTS

PIRSF

SMART

SM00229
SM00147
SM00109

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8BTM9