Version 5.4
Mus musculus Gene: Rasgrp4
Summary
InnateDB Gene IDBG-165997.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rasgrp4
Gene Name RAS guanyl releasing protein 4
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000030589
Encoded Proteins
IDBP-165999
RAS guanyl releasing protein 4
IDBP-166118
RAS guanyl releasing protein 4
IDBP-538372
RAS guanyl releasing protein 4
IDBP-534347
RAS guanyl releasing protein 4
IDBP-534462
RAS guanyl releasing protein 4
IDBP-541978
RAS guanyl releasing protein 4
IDBP-539181
RAS guanyl releasing protein 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000171777:
The protein encoded by this gene is a member of the Ras guanyl nucleotide-releasing protein (RasGRP) family of Ras guanine nucleotide exchange factors. It contains a Ras exchange motif, a diacylglycerol-binding domain, and two calcium-binding EF hands. This protein was shown to activate H-Ras in a cation-dependent manner in vitro. Expression of this protein in myeloid cell lines was found to be correlated with elevated level of activated RAS protein, and the RAS activation can be greatly enhanced by phorbol ester treatment, which suggested a role of this protein in diacylglycerol regulated cell signaling pathways. Studies of a mast cell leukemia cell line expressing substantial amounts of abnormal transcripts of this gene indicated that this gene may play an important role in the final stages of mast cell development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:29134854-29153961
Strand Forward strand
Band B1
Transcripts
ENSMUST00000094617 ENSMUSP00000092200
ENSMUST00000032811 ENSMUSP00000032811
ENSMUST00000161522 ENSMUSP00000123718
ENSMUST00000159975 ENSMUSP00000125137
ENSMUST00000162946
ENSMUST00000159898
ENSMUST00000160194 ENSMUSP00000124908
ENSMUST00000159351 ENSMUSP00000124183
ENSMUST00000160396 ENSMUSP00000125544
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0046872 metal ion binding
Biological Process
GO:0007264 small GTPase mediated signal transduction
GO:0008283 cell proliferation
GO:0009991 response to extracellular stimulus
GO:0016049 cell growth
GO:0030154 cell differentiation
GO:0032318 regulation of Ras GTPase activity
GO:0032320 positive regulation of Ras GTPase activity
GO:0035556 intracellular signal transduction
GO:0043087 regulation of GTPase activity
GO:0046579 positive regulation of Ras protein signal transduction
GO:0051056 regulation of small GTPase mediated signal transduction
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000171777
View Gene Order
ENSBTAG00000006998
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04010
MAPK signaling pathway pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_163994
FCERI mediated NF-kB activation pathway
REACT_6802
Innate Immune System pathway
REACT_163936
Fc epsilon receptor (FCERI) signaling pathway
REACT_6900
Immune System pathway
KEGG
hsa04010
MAPK signaling pathway pathway
INOH
PID NCI
ras_pathway
Regulation of Ras family activation
Cross-References
SwissProt Q8BTM9
TrEMBL
UniProt Splice Variant
Entrez Gene 233046
UniGene Mm.465324
RefSeq NM_001174155 NM_145149 XM_006539871
OMIM
CCDS
HPRD
IMGT
MGI ID MGI:2386851
MGI Symbol Rasgrp4
EMBL AF331457 AK049562 AK089282 AK154746 AK162667 AK165106 AY040628 AY196476
GenPept AAK81694 AAK84299 AAO20841 BAC33811 BAC40827 BAE32802 BAE37013 BAE38037
RNA Seq Atlas 233046

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca