Version 5.4
Mus musculus Protein: Nr3c1
Summary
InnateDB Protein IDBP-542036.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nr3c1
Protein Name nuclear receptor subfamily 3, group C, member 1
Synonyms GR; Grl-1; Grl1;
Species Mus musculus
Ensembl Protein ENSMUSP00000120082
InnateDB Gene IDBG-142259 (Nr3c1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 180 interaction(s) predicted by orthology.
Experimentally validated
Total 32 [view]
Protein-Protein 31 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 180 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0004883 glucocorticoid receptor activity
GO:0005496 steroid binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
GO:0046983 protein dimerization activity
Biological Process
GO:0006111 regulation of gluconeogenesis
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0008211 glucocorticoid metabolic process
GO:0030325 adrenal gland development
GO:0031946 regulation of glucocorticoid biosynthetic process
GO:0042921 glucocorticoid receptor signaling pathway
GO:0043402 glucocorticoid mediated signaling pathway
GO:0043525 positive regulation of neuron apoptotic process
GO:0045087 innate immune response (InnateDB)
GO:0060603 mammary gland duct morphogenesis
GO:1900170 negative regulation of glucocorticoid mediated signaling pathway
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
Protein Structure and Domains
PDB ID MGI:95824
InterPro IPR001409 Glucocorticoid receptor
IPR001628 Zinc finger, nuclear hormone receptor-type
PFAM PF02155
PF00105
PRINTS PR00528
PR00047
PIRSF
SMART SM00399
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL E9Q8A6
UniProt Splice Variant
Entrez Gene 14815
UniGene Mm.471524
RefSeq
MGI ID
MGI Symbol Nr3c1
OMIM
CCDS
HPRD
IMGT
EMBL AC007995 AC124417 EU118151 EU118152
GenPept ABV31979 ABV31980

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca