InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Htra2

Summary

InnateDB Protein

IDBP-542082.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Htra2

Protein Name

HtrA serine peptidase 2

Synonyms

AI481710; mnd2; Omi; Prss25;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000115547

InnateDB Gene

IDBG-159586 (Htra2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 50 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	50 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0005515	protein binding

Biological Process

GO:0006508	proteolysis
GO:0007005	mitochondrion organization
GO:0007628	adult walking behavior
GO:0008344	adult locomotory behavior
GO:0030900	forebrain development
GO:0040014	regulation of multicellular organism growth
GO:0048666	neuron development
GO:0097193	intrinsic apoptotic signaling pathway

Cellular Component

GO:0005739	mitochondrion
GO:0005758	mitochondrial intermembrane space

Protein Structure and Domains

PDB ID

MGI:1928676

InterPro

IPR001254 Peptidase S1
IPR001478 PDZ domain
IPR001940 Peptidase S1C
IPR009003 Trypsin-like cysteine/serine peptidase domain

PFAM

PF00089
PF00595
PF13180

PRINTS

PR00834

PIRSF

SMART

SM00020
SM00228

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

F6TCV0

UniProt Splice Variant

Entrez Gene

64704

UniGene

Mm.21880

RefSeq

MGI ID

MGI Symbol

Htra2

OMIM

CCDS

HPRD

IMGT

EMBL

AC104324

GenPept