InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Becn1

Summary

InnateDB Protein

IDBP-542128.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Becn1

Protein Name

beclin 1, autophagy related

Synonyms

4921513J16Rik; 5430417M23Rik; Atg6;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000119369

InnateDB Gene

IDBG-212053 (Becn1)

Protein Structure

UniProt Annotation

Function

Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. {ECO:0000269PubMed:10604474, ECO:0000269PubMed:12372286, ECO:0000269PubMed:19270693}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:12372286}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Interaction with ATG14 promotes translocation to autophagosomes (By similarity). Expressed in dendrites and cell bodies of cerebellar Purkinje cells. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 65 interaction(s) predicted by orthology.

Experimentally validated
Total	36 [view]
Protein-Protein	36 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	65 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000045	autophagic vacuole assembly
GO:0000910	cytokinesis
GO:0001666	response to hypoxia
GO:0006914	autophagy
GO:0007040	lysosome organization
GO:0008285	negative regulation of cell proliferation
GO:0016239	positive regulation of macroautophagy
GO:0033197	response to vitamin E
GO:0042493	response to drug
GO:0048666	neuron development
GO:0050435	beta-amyloid metabolic process
GO:0050790	regulation of catalytic activity
GO:0051607	defense response to virus
GO:0051707	response to other organism
GO:0060548	negative regulation of cell death
GO:0071275	cellular response to aluminum ion
GO:0071364	cellular response to epidermal growth factor stimulus

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005802	trans-Golgi network
GO:0005856	cytoskeleton
GO:0016020	membrane
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0030425	dendrite
GO:0043234	protein complex
GO:0045335	phagocytic vesicle