Version 5.4
Mus musculus Gene: Becn1
Summary
InnateDB Gene IDBG-212053.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Becn1
Gene Name beclin 1, autophagy related
Synonyms 4921513J16Rik; 5430417M23Rik; Atg6
Species Mus musculus
Ensembl Gene ENSMUSG00000035086
Encoded Proteins
IDBP-212057
beclin 1, autophagy related
IDBP-542128
beclin 1, autophagy related
IDBP-532115
beclin 1, autophagy related
IDBP-540508
beclin 1, autophagy related
IDBP-536920
beclin 1, autophagy related
IDBP-619906
beclin 1, autophagy related
IDBP-619907
beclin 1, autophagy related
IDBP-619909
beclin 1, autophagy related
IDBP-619910
beclin 1, autophagy related
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 18772134
[Homo sapiens] BECN1 is recruited into the mouse Myd88 and Ticam TLR-signalling complex thereby reducing its binding to Bcl2, leading to autophagy.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000126581:
Beclin-1 participates in the regulation of autophagy and has an important role in development, tumorigenesis, and neurodegeneration (Zhong et al., 2009 [PubMed 19270693]).[supplied by OMIM, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:101285952-101302286
Strand Reverse strand
Band D
Transcripts
ENSMUST00000041403 ENSMUSP00000040094
ENSMUST00000130916 ENSMUSP00000119369
ENSMUST00000122817
ENSMUST00000139997
ENSMUST00000136535
ENSMUST00000135805
ENSMUST00000129863 ENSMUSP00000116580
ENSMUST00000126195 ENSMUSP00000122168
ENSMUST00000140286
ENSMUST00000140706 ENSMUSP00000122412
ENSMUST00000139669
ENSMUST00000137614
ENSMUST00000172233 ENSMUSP00000129156
ENSMUST00000167667 ENSMUSP00000130951
ENSMUST00000167818 ENSMUSP00000131629
ENSMUST00000170502 ENSMUSP00000128413
ENSMUST00000164036
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 65 interaction(s) predicted by orthology.
Experimentally validated
Total 36 [view]
Protein-Protein 36 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 65 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0000045 autophagic vacuole assembly
GO:0000910 cytokinesis
GO:0001666 response to hypoxia
GO:0006914 autophagy
GO:0007040 lysosome organization
GO:0008285 negative regulation of cell proliferation
GO:0016239 positive regulation of macroautophagy
GO:0033197 response to vitamin E
GO:0042493 response to drug
GO:0048666 neuron development
GO:0050435 beta-amyloid metabolic process
GO:0050790 regulation of catalytic activity
GO:0051607 defense response to virus
GO:0051707 response to other organism
GO:0060548 negative regulation of cell death
GO:0071275 cellular response to aluminum ion
GO:0071364 cellular response to epidermal growth factor stimulus
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005802 trans-Golgi network
GO:0005856 cytoskeleton
GO:0016020 membrane
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0030425 dendrite
GO:0043234 protein complex
GO:0045335 phagocytic vesicle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000126581
View Gene Order
ENSBTAG00000019914
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04140
Regulation of autophagy pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04140
Regulation of autophagy pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.178947 Mm.400378
RefSeq NM_019584
OMIM
CCDS CCDS25462
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca