InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Faf2

Summary

InnateDB Protein

IDBP-542216.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Faf2

Protein Name

Fas associated factor family member 2

Synonyms

2210404D11Rik; AI462440; mKIAA0887; Ubxd8;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000121182

InnateDB Gene

IDBG-153931 (Faf2)

Protein Structure

UniProt Annotation

Function

May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome. {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Lipid droplet {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 69 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	69 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0031625	ubiquitin protein ligase binding
GO:0035473	lipase binding
GO:0043130	ubiquitin binding
GO:0055102	lipase inhibitor activity

Biological Process

GO:0006986	response to unfolded protein
GO:0034389	lipid particle organization
GO:0043086	negative regulation of catalytic activity

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005811	lipid particle
GO:0034098	Cdc48p-Npl4p-Ufd1p AAA ATPase complex
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

MGI:1923827

InterPro

IPR000449 Ubiquitin-associated domain/translation elongation factor EF-Ts, N-terminal
IPR001012 UBX domain
IPR006577 UAS
IPR009060 UBA-like
IPR029071 Ubiquitin-related domain

PFAM

PF00627
PF00789

PRINTS

PIRSF

SMART

SM00166
SM00594

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q3TDN2