Version 5.4
Mus musculus Protein: Ctsd
Summary
InnateDB Protein IDBP-542281.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ctsd
Protein Name cathepsin D
Synonyms CatD; CD;
Species Mus musculus
Ensembl Protein ENSMUSP00000121203
InnateDB Gene IDBG-212523 (Ctsd)
Protein Structure
UniProt Annotation
Function Acid protease active in intracellular protein breakdown.
Subcellular Localization Lysosome. Melanosome {ECO:0000250}. Secreted, extracellular space {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
Experimentally validated
Total 16 [view]
Protein-Protein 15 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 18 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004190 aspartic-type endopeptidase activity
GO:0008233 peptidase activity
Biological Process
GO:0000045 autophagic vacuole assembly
GO:0006508 proteolysis
Cellular Component
GO:0005615 extracellular space
GO:0005739 mitochondrion
GO:0005764 lysosome
GO:0031012 extracellular matrix
GO:0042470 melanosome
Protein Structure and Domains
PDB ID MGI:88562
InterPro IPR001461 Aspartic peptidase
IPR012848 Aspartic peptidase, N-terminal
IPR021109 Aspartic peptidase domain
PFAM PF00026
PF07966
PRINTS PR00792
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P18242
PhosphoSite PhosphoSite-P18242
TrEMBL Q3UCD9
UniProt Splice Variant
Entrez Gene 13033
UniGene Mm.392048
RefSeq NP_034113
MGI ID
MGI Symbol Ctsd
OMIM
CCDS CCDS22029
HPRD
IMGT
EMBL AC034099 AK150364 AK150579 AK150694 AK150768 AK150946 AK151256 AK151275 AK151374 AK151829 AK151962 AK152036 AK152168 AK152187 AK152188 AK152406 AK152458 AK152567 AK152593 AK152680 AK152828 AK152881 AK152892 AK153191 AK159097 AK159440 AK159512 AK159970 AK166864 AK166938 AK167143 AK167867 AK169139 AK171195 BC048900 BC054758 BC057931 CH466531 X52886 X53337 X68378 X68379 X68380 X68381 X68382 X68383
GenPept AAH48900 AAH54758 AAH57931 BAE29499 BAE29674 BAE29773 BAE29834 BAE29980 BAE30245 BAE30262 BAE30346 BAE30724 BAE30833 BAE30895 BAE31001 BAE31018 BAE31019 BAE31193 BAE31236 BAE31319 BAE31342 BAE31412 BAE31529 BAE31566 BAE31575 BAE31791 BAE34813 BAE35086 BAE35144 BAE35523 BAE39078 BAE39131 BAE39288 BAE39883 BAE40918 BAE42305 CAA37067 CAA37423 CAA48453 EDL18142

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca