Version 5.4
Mus musculus Gene: Ctsd
Summary
InnateDB Gene IDBG-212523.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ctsd
Gene Name cathepsin D
Synonyms CatD; CD
Species Mus musculus
Ensembl Gene ENSMUSG00000007891
Encoded Proteins
IDBP-212525
cathepsin D
IDBP-542475
cathepsin D
IDBP-542281
cathepsin D
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 18762176
[Homo sapiens] Cathepsins: key modulators of cell death and inflammatory responses
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000117984:
This gene encodes a lysosomal aspartyl protease composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. This proteinase, which is a member of the peptidase C1 family, has a specificity similar to but narrower than that of pepsin A. Transcription of this gene is initiated from several sites, including one which is a start site for an estrogen-regulated transcript. Mutations in this gene are involved in the pathogenesis of several diseases, including breast cancer and possibly Alzheimer disease. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:142371148-142388038
Strand Reverse strand
Band F5
Transcripts
ENSMUST00000066401 ENSMUSP00000063904
ENSMUST00000133843 ENSMUSP00000117247
ENSMUST00000151120 ENSMUSP00000121203
ENSMUST00000153679
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
Experimentally validated
Total 16 [view]
Protein-Protein 15 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 18 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004190 aspartic-type endopeptidase activity
GO:0008233 peptidase activity
Biological Process
GO:0000045 autophagic vacuole assembly
GO:0006508 proteolysis
Cellular Component
GO:0005615 extracellular space
GO:0005739 mitochondrion
GO:0005764 lysosome
GO:0031012 extracellular matrix
GO:0042470 melanosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000117984
View Gene Order
ENSBTAG00000007622
Not yet available
Pathways
NETPATH
REACTOME
REACT_230745
Immune System pathway
REACT_206066
Extracellular matrix organization pathway
REACT_196550
MHC class II antigen presentation pathway
REACT_229531
Adaptive Immune System pathway
REACT_199052
Degradation of the extracellular matrix pathway
REACT_199055
Collagen degradation pathway
KEGG
mmu04142
Lysosome pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_56
Prolactin pathway
REACTOME
REACT_121399
MHC class II antigen presentation pathway
REACT_147707
Metabolism of Angiotensinogen to Angiotensins pathway
REACT_150401
Collagen degradation pathway
REACT_118779
Extracellular matrix organization pathway
REACT_118572
Degradation of the extracellular matrix pathway
REACT_17015
Metabolism of proteins pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_160078
Peptide hormone metabolism pathway
KEGG
hsa04142
Lysosome pathway
INOH
PID NCI
ceramide_pathway
Ceramide signaling pathway
era_genomic_pathway
Validated nuclear estrogen receptor alpha network
p53downstreampathway
Direct p53 effectors
lkb1_pathway
LKB1 signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.231395 Mm.392048
RefSeq NM_009983
OMIM
CCDS CCDS22029
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca