InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ttc3

Summary

InnateDB Protein

IDBP-542361.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ttc3

Protein Name

tetratricopeptide repeat domain 3

Synonyms

2610202A04Rik; AA409221; D16Ium21; D16Ium21e; mKIAA4119; TPRD;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000116896

InnateDB Gene

IDBG-178662 (Ttc3)

Protein Structure

UniProt Annotation

Function

E3 ubiquitin-protein ligase that mediates the ubiquitination and subsequent degradation of phosphorylated Akt (AKT1, AKT2 and AKT3) in the nucleus. Acts as a terminal regulator of Akt signaling after activation; its phosphorylation by Akt, which is a prerequisite for ubiquitin ligase activity, suggests the existence of a regulation mechanism required to control Akt levels after activation. Catalyzes the formation of 'Lys-48'- polyubiquitin chains. May play a role in neuronal differentiation inhibition via its interaction with CIT (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity

Biological Process

GO:0006511	ubiquitin-dependent protein catabolic process
GO:0010771	negative regulation of cell morphogenesis involved in differentiation
GO:0045665	negative regulation of neuron differentiation
GO:0070936	protein K48-linked ubiquitination