Version 5.4
Mus musculus Protein: Ggct
Summary
InnateDB Protein IDBP-542383.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ggct
Protein Name gamma-glutamyl cyclotransferase
Synonyms A030007L17Rik; AA673177; Gctg; Ggc;
Species Mus musculus
Ensembl Protein ENSMUSP00000120154
InnateDB Gene IDBG-149409 (Ggct)
Protein Structure
UniProt Annotation
Function Catalyzes the formation of 5-oxoproline from gamma- glutamyl dipeptides and may play a significant role in glutathione homeostasis. Induces release of cytochrome c from mitochondria with resultant induction of apoptosis (By similarity). {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003839 gamma-glutamylcyclotransferase activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0001836 release of cytochrome c from mitochondria
GO:0006750 glutathione biosynthetic process
Cellular Component
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:95700
InterPro IPR009288 AIG2-like
IPR013024 Butirosin biosynthesis, BtrG-like
PFAM PF06094
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9D7X8
PhosphoSite PhosphoSite-Q9D7X8
TrEMBL
UniProt Splice Variant
Entrez Gene 110175
UniGene Mm.294708
RefSeq NP_080913
MGI ID
MGI Symbol Ggct
OMIM
CCDS CCDS20161
HPRD
IMGT
EMBL AK008719 AK050049 AK079465 AK141474 BC080818 CH466597
GenPept AAH80818 BAB25854 BAC34049 BAC37656 BAE24696 EDK98717

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca