InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Irf9

Summary

InnateDB Protein

IDBP-542465.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Irf9

Protein Name

interferon regulatory factor 9

Synonyms

Irf-9; Isgf3g; p48;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000120359

InnateDB Gene

IDBG-164579 (Irf9)

Protein Structure

UniProt Annotation

Function

Transcription factor that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. IRF9/ISGF3G associateswith the phosphorylated STAT1:STAT2 dimer to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 43 interaction(s) predicted by orthology.

Experimentally validated
Total	21 [view]
Protein-Protein	11 [view]
Protein-DNA	10 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	43 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000975	regulatory region DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding