Version 5.4
Mus musculus Gene: Irf9
Summary
InnateDB Gene IDBG-164579.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Irf9
Gene Name interferon regulatory factor 9
Synonyms Irf-9; Isgf3g; p48
Species Mus musculus
Ensembl Gene ENSMUSG00000002325
Encoded Proteins
IDBP-532461
interferon regulatory factor 9
IDBP-542465
interferon regulatory factor 9
IDBP-542757
interferon regulatory factor 9
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 9242679
[Homo sapiens] IRF9 is a DNA-binding protein that is a member of the alpha-interferon-induced ISGF3 complex. Bipartite complexes of STAT2:IRF9 and STAT2:STAT1 translocate to the nucleus and associate on DNA target sites as ISGF3.
PMID 15194680
[Homo sapiens] IRF9 functions to recruit RNA polymerase II to the promoter of interferon (IFN)-stimulated genes and this function of IRF9 requires the activity of histone deacetylases.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000213928:
Gene Information
Type Protein coding
Genomic Location Chromosome 14:55603571-55610030
Strand Forward strand
Band C3
Transcripts
ENSMUST00000134863 ENSMUSP00000120525
ENSMUST00000130697 ENSMUSP00000120359
ENSMUST00000136109
ENSMUST00000138037 ENSMUSP00000119477
ENSMUST00000145680
ENSMUST00000126269
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 43 interaction(s) predicted by orthology.
Experimentally validated
Total 21 [view]
Protein-Protein 11 [view]
Protein-DNA 10 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 43 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000975 regulatory region DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0045351 type I interferon biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000213928
View Gene Order
ENSBTAG00000005816
Not yet available
Pathways
NETPATH
REACTOME
REACT_233584
Cytokine Signaling in Immune system pathway
REACT_230745
Immune System pathway
REACT_198660
Interferon gamma signaling pathway
REACT_198666
Interferon Signaling pathway
REACT_198622
Interferon alpha/beta signaling pathway
KEGG
mmu04630
Jak-STAT signaling pathway pathway
mmu04380
Osteoclast differentiation pathway
mmu05160
Hepatitis C pathway
INOH
INOH website
IFN alpha signaling pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_25162
Interferon alpha/beta signaling pathway
REACT_25078
Interferon gamma signaling pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_25229
Interferon Signaling pathway
REACT_6900
Immune System pathway
KEGG
hsa04630
Jak-STAT signaling pathway pathway
hsa04380
Osteoclast differentiation pathway
hsa05160
Hepatitis C pathway
INOH
INOH website
IFN alpha signaling pathway
PID NCI
ifngpathway
IFN-gamma pathway
Cross-References
SwissProt Q61179
TrEMBL E9PZJ2 E9Q8M6 Q3UKQ7
UniProt Splice Variant
Entrez Gene 16391
UniGene Mm.2032
RefSeq NM_001159417 NM_001159418 NM_008394
OMIM
CCDS CCDS27119 CCDS49496 CCDS49497
HPRD
IMGT
MGI ID MGI:107587
MGI Symbol Irf9
EMBL AC174678 AK145911 BC005435 BC012968 CH466535 U51992
GenPept AAC52494 AAH05435 AAH12968 BAE26744 EDL36274
RNA Seq Atlas 16391

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca