InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Glrx2

Summary

InnateDB Protein

IDBP-542467.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Glrx2

Protein Name

glutaredoxin 2 (thioltransferase)

Synonyms

1700010P22Rik; AI645710; Grx2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000121010

InnateDB Gene

IDBG-196991 (Glrx2)

Protein Structure

UniProt Annotation

Function

Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release. {ECO:0000269PubMed:11397793, ECO:0000269PubMed:15347644}.

Subcellular Localization

Isoform 1: Mitochondrion.Isoform 2: Nucleus.

Disease Associations

Tissue Specificity

Widely expressed. Highly expressed in testis, and at much lower level in kidney and brain. {ECO:0000269PubMed:12954614}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0009055	electron carrier activity
GO:0015035	protein disulfide oxidoreductase activity
GO:0046872	metal ion binding
GO:0051537	2 iron, 2 sulfur cluster binding