Version 5.4
Mus musculus Protein: Cenpo
Summary
InnateDB Protein IDBP-542643.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cenpo
Protein Name centromere protein O
Synonyms 2810429O05Rik; 8430427C03Rik; D12Ertd482e;
Species Mus musculus
Ensembl Protein ENSMUSP00000119136
InnateDB Gene IDBG-127915 (Cenpo)
Protein Structure
UniProt Annotation
Function Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Modulates the kinetochore-bound levels of NDC80 complex (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Chromosome, centromere {ECO:0000250}. Chromosome, centromere, kinetochore {ECO:0000250}. Note=Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 18 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0008150 biological_process
GO:0034508 centromere complex assembly
Cellular Component
GO:0000776 kinetochore
GO:0000777 condensed chromosome kinetochore
GO:0005634 nucleus
Protein Structure and Domains
PDB ID MGI:1923800
InterPro IPR018464 Centromere protein O
PFAM PF09496
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8K015
PhosphoSite PhosphoSite-Q8K015
TrEMBL B8JK52
UniProt Splice Variant
Entrez Gene 52504
UniGene Mm.70546
RefSeq NP_598807
MGI ID
MGI Symbol Cenpo
OMIM
CCDS CCDS25788
HPRD
IMGT
EMBL AC162932 AK013198 AK029226 AK134266 BC023148 BC034399 CH466623 CT572999
GenPept AAH23148 AAH34399 BAB28707 BAC26354 BAE22073 EDL01373

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca