InnateDB Protein
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IDBP-542795.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Srsf3
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Protein Name
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serine/arginine-rich splicing factor 3
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Synonyms
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AL024116; Sfrs3; X16;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000117045
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InnateDB Gene
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IDBG-159792 (Srsf3)
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Protein Structure
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Function |
May be involved in RNA processing in relation with cellular proliferation and/or maturation. May function as export adapter involved in mRNA nuclear export such as of histone H2A. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA- binding activity. RNA-binding is semi-sequence specific (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Highest expression in thymus and pre-B cell lines; high, in testis, brain and spleen; very low in heart and not detectable in liver and kidney. {ECO:0000269PubMed:2030943}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 93 interaction(s) predicted by orthology.
Experimentally validated |
Total |
14
[view]
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Protein-Protein |
14
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
93 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:98285
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InterPro |
IPR000504
RNA recognition motif domain
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PFAM |
PF00076
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PRINTS |
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PIRSF |
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SMART |
SM00360
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TIGRFAMs |
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Modification |
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SwissProt |
P84104
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PhosphoSite |
PhosphoSite-P84104
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
20383
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UniGene |
Mm.6787
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RefSeq |
NP_038691
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MGI ID |
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MGI Symbol |
Srsf3
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OMIM |
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CCDS |
CCDS28590
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HPRD |
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IMGT |
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EMBL |
AK011657
AK078891
AK134177
AK135298
AK145089
AK145715
AK146010
AK146253
AK150912
AK153209
BC068111
BC071196
BC083316
X53824
X91656
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GenPept |
AAH68111
AAH71196
AAH83316
BAB27762
BAC37445
BAE22040
BAE22483
BAE26230
BAE26606
BAE26830
BAE27015
BAE29950
BAE31808
CAA37821
CAA62844
CAA62845
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