Version 5.4
Mus musculus Protein: Pik3cb
Summary
InnateDB Protein IDBP-542797.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pik3cb
Protein Name phosphatidylinositol 3-kinase, catalytic, beta polypeptide
Synonyms 1110001J02Rik; AI447572; p110beta;
Species Mus musculus
Ensembl Protein ENSMUSP00000121466
InnateDB Gene IDBG-192637 (Pik3cb)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.
Experimentally validated
Total 21 [view]
Protein-Protein 20 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 21 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0016303 1-phosphatidylinositol-3-kinase activity
GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity
GO:0043560 insulin receptor substrate binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
Biological Process
GO:0001952 regulation of cell-matrix adhesion
GO:0006874 cellular calcium ion homeostasis
GO:0007156 homophilic cell adhesion
GO:0030168 platelet activation
GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process
GO:0040016 embryonic cleavage
GO:0046854 phosphatidylinositol phosphorylation
GO:0048015 phosphatidylinositol-mediated signaling
Cellular Component
GO:0005886 plasma membrane
GO:0005942 phosphatidylinositol 3-kinase complex
Protein Structure and Domains
PDB ID MGI:1922019
InterPro IPR003113 Phosphatidylinositol 3-kinase adaptor-binding (PI3K ABD) domain
IPR029071 Ubiquitin-related domain
PFAM PF02192
PRINTS
PIRSF
SMART SM00143
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL D3Z2Z7
UniProt Splice Variant
Entrez Gene 74769
UniGene Mm.213128
RefSeq
MGI ID
MGI Symbol Pik3cb
OMIM
CCDS
HPRD
IMGT
EMBL AC120148 AC122930
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca