Version 5.4
| Mus musculus Gene: Pik3cb | |||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Summary | |||||||||||||||||||||||
| InnateDB Gene | IDBG-192637.6 | ||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
| Gene Symbol | Pik3cb | ||||||||||||||||||||||
| Gene Name | phosphatidylinositol 3-kinase, catalytic, beta polypeptide | ||||||||||||||||||||||
| Synonyms | 1110001J02Rik; AI447572; p110beta | ||||||||||||||||||||||
| Species | Mus musculus | ||||||||||||||||||||||
| Ensembl Gene | ENSMUSG00000032462 | ||||||||||||||||||||||
| Encoded Proteins |
phosphatidylinositol 3-kinase, catalytic, beta polypeptide
phosphatidylinositol 3-kinase, catalytic, beta polypeptide
phosphatidylinositol 3-kinase, catalytic, beta polypeptide
|
||||||||||||||||||||||
| Protein Structure | |||||||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
| InnateDB Annotation from Orthologs | |||||||||||||||||||||||
| Summary |
[Homo sapiens] PIK3CA and PIK3CB isoforms of class IA phosphatidylinositol 3-kinase (PI3K) are both required for the pro-inflammatory response to flagellin.
|
||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000051382:
This gene encodes an isoform of the catalytic subunit of phosphoinositide 3-kinase (PI3K). These kinases are important in signaling pathways involving receptors on the outer membrane of eukaryotic cells and are named for their catalytic subunit. The encoded protein is the catalytic subunit for PI3Kbeta (PI3KB). PI3KB has been shown to be part of the activation pathway in neutrophils which have bound immune complexes at sites of injury or infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011] |
||||||||||||||||||||||
| Gene Information | |||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||
| Genomic Location | Chromosome 9:99036654-99140621 | ||||||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||||||
| Band | E3.3 | ||||||||||||||||||||||
| Transcripts |
|
||||||||||||||||||||||
| Interactions | |||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.
|
||||||||||||||||||||||
| Gene Ontology | |||||||||||||||||||||||
Molecular Function |
|
||||||||||||||||||||||
| Biological Process |
|
||||||||||||||||||||||
| Cellular Component |
|
||||||||||||||||||||||
| Orthologs | |||||||||||||||||||||||
|
Species
Homo sapiens
Bos taurus
|
Gene ID
Gene Order
Not yet available
|
||||||||||||||||||||||
| Pathways | |||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||
| REACTOME |
Innate Immune System pathway
Signaling by the B Cell Receptor (BCR) pathway
Signaling by ERBB2 pathway
GPCR downstream signaling pathway
PI3K/AKT activation pathway
Synthesis of PIPs at the plasma membrane pathway
Disease pathway
Hemostasis pathway
Nephrin interactions pathway
Signaling by GPCR pathway
Signaling by Insulin receptor pathway
Interleukin-2 signaling pathway
Role of phospholipids in phagocytosis pathway
Downstream TCR signaling pathway
Signaling by VEGF pathway
Signaling by FGFR in disease pathway
Signaling by ERBB4 pathway
Signaling by SCF-KIT pathway
PI Metabolism pathway
Cytokine Signaling in Immune system pathway
PIP3 activates AKT signaling pathway
Cell surface interactions at the vascular wall pathway
Metabolism pathway
Immune System pathway
Platelet activation, signaling and aggregation pathway
Metabolism of lipids and lipoproteins pathway
Downstream signal transduction pathway
Downstream signaling of activated FGFR pathway
Constitutive PI3K/AKT Signaling in Cancer pathway
PI3K events in ERBB4 signaling pathway
PI-3K cascade pathway
Signaling by EGFR pathway
GPVI-mediated activation cascade pathway
Insulin receptor signalling cascade pathway
IRS-related events triggered by IGF1R pathway
IGF1R signaling cascade pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
Interleukin receptor SHC signaling pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
PI3K Cascade pathway
VEGFA-VEGFR2 Pathway pathway
Fc epsilon receptor (FCERI) signaling pathway
Signaling by Interleukins pathway
PI3K/AKT Signaling in Cancer pathway
Fcgamma receptor (FCGR) dependent phagocytosis pathway
Signalling by NGF pathway
Adaptive Immune System pathway
Signaling by PDGF pathway
GAB1 signalosome pathway
Phospholipid metabolism pathway
IRS-related events pathway
NGF signalling via TRKA from the plasma membrane pathway
IRS-mediated signalling pathway
G-protein beta:gamma signalling pathway
Interleukin-3, 5 and GM-CSF signaling pathway
PI3K events in ERBB2 signaling pathway
Signal Transduction pathway
Tie2 Signaling pathway
G beta:gamma signalling through PI3Kgamma pathway
Signaling by FGFR pathway
Cell-Cell communication pathway
TCR signaling pathway
Signaling by EGFR in Cancer pathway
Regulation of signaling by CBL pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
DAP12 interactions pathway
DAP12 signaling pathway
|
||||||||||||||||||||||
| KEGG |
Endometrial cancer pathway
Renal cell carcinoma pathway
ErbB signaling pathway pathway
Type II diabetes mellitus pathway
VEGF signaling pathway pathway
Jak-STAT signaling pathway pathway
Insulin signaling pathway pathway
Acute myeloid leukemia pathway
T cell receptor signaling pathway pathway
Toll-like receptor signaling pathway pathway
Colorectal cancer pathway
Fc epsilon RI signaling pathway pathway
Melanoma pathway
Natural killer cell mediated cytotoxicity pathway
Phosphatidylinositol signaling system pathway
Regulation of actin cytoskeleton pathway
Glioma pathway
mTOR signaling pathway pathway
Small cell lung cancer pathway
Leukocyte transendothelial migration pathway
Apoptosis pathway
Prostate cancer pathway
Chronic myeloid leukemia pathway
Inositol phosphate metabolism pathway
Non-small cell lung cancer pathway
Focal adhesion pathway
B cell receptor signaling pathway pathway
Pancreatic cancer pathway
Fc gamma R-mediated phagocytosis pathway
Chemokine signaling pathway pathway
Neurotrophin signaling pathway pathway
Pathways in cancer pathway
Progesterone-mediated oocyte maturation pathway
Aldosterone-regulated sodium reabsorption pathway
Amoebiasis pathway
Osteoclast differentiation pathway
Carbohydrate digestion and absorption pathway
Toxoplasmosis pathway
Hepatitis C pathway
Chagas disease (American trypanosomiasis) pathway
Bacterial invasion of epithelial cells pathway
|
||||||||||||||||||||||
| INOH | |||||||||||||||||||||||
| PID NCI | |||||||||||||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
| NETPATH |
Alpha6Beta4Integrin pathway
EGFR1 pathway
IL2 pathway
Prolactin pathway
|
||||||||||||||||||||||
| REACTOME |
PIP3 activates AKT signaling pathway
DAP12 signaling pathway
DAP12 interactions pathway
Role of phospholipids in phagocytosis pathway
Downstream TCR signaling pathway
Regulation of signaling by CBL pathway
Interleukin receptor SHC signaling pathway
Interleukin-3, 5 and GM-CSF signaling pathway
Interleukin-2 signaling pathway
Tie2 Signaling pathway
Cell surface interactions at the vascular wall pathway
GPVI-mediated activation cascade pathway
PI3K/AKT activation pathway
GAB1 signalosome pathway
Signaling by EGFR pathway
G beta:gamma signalling through PI3Kgamma pathway
PI3K events in ERBB4 signaling pathway
Signaling by ERBB4 pathway
PI3K Cascade pathway
Signaling by Insulin receptor pathway
IRS-related events triggered by IGF1R pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
PI3K events in ERBB2 signaling pathway
Signaling by ERBB2 pathway
PI-3K cascade pathway
Signaling by FGFR pathway
Signaling by SCF-KIT pathway
Downstream signal transduction pathway
Signaling by PDGF pathway
Synthesis of PIPs at the plasma membrane pathway
Constitutive PI3K/AKT Signaling in Cancer pathway
Nephrin interactions pathway
Signaling by FGFR in disease pathway
Signalling by NGF pathway
Signaling by EGFR in Cancer pathway
Downstream signaling of activated FGFR pathway
Metabolism of lipids and lipoproteins pathway
Cell-Cell communication pathway
TCR signaling pathway
Signaling by VEGF pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Cytokine Signaling in Immune system pathway
Signaling by GPCR pathway
Innate Immune System pathway
Platelet activation, signaling and aggregation pathway
G-protein beta:gamma signalling pathway
Fc epsilon receptor (FCERI) signaling pathway
Signal Transduction pathway
GPCR downstream signaling pathway
IRS-mediated signalling pathway
Adaptive Immune System pathway
Immune System pathway
Insulin receptor signalling cascade pathway
Signaling by Interleukins pathway
VEGFA-VEGFR2 Pathway pathway
NGF signalling via TRKA from the plasma membrane pathway
PI Metabolism pathway
Phospholipid metabolism pathway
IRS-related events pathway
Fcgamma receptor (FCGR) dependent phagocytosis pathway
IGF1R signaling cascade pathway
PI3K/AKT Signaling in Cancer pathway
Metabolism pathway
Signaling by the B Cell Receptor (BCR) pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
Disease pathway
Hemostasis pathway
|
||||||||||||||||||||||
| KEGG |
Regulation of actin cytoskeleton pathway
mTOR signaling pathway pathway
Acute myeloid leukemia pathway
VEGF signaling pathway pathway
Fc epsilon RI signaling pathway pathway
Colorectal cancer pathway
Non-small cell lung cancer pathway
Inositol phosphate metabolism pathway
ErbB signaling pathway pathway
Renal cell carcinoma pathway
Apoptosis pathway
Melanoma pathway
Endometrial cancer pathway
Leukocyte transendothelial migration pathway
Glioma pathway
Small cell lung cancer pathway
Phosphatidylinositol signaling system pathway
Insulin signaling pathway pathway
B cell receptor signaling pathway pathway
Prostate cancer pathway
Focal adhesion pathway
T cell receptor signaling pathway pathway
Toll-like receptor signaling pathway pathway
Jak-STAT signaling pathway pathway
Type II diabetes mellitus pathway
Natural killer cell mediated cytotoxicity pathway
Chronic myeloid leukemia pathway
Pancreatic cancer pathway
Fc gamma R-mediated phagocytosis pathway
Neurotrophin signaling pathway pathway
Chemokine signaling pathway pathway
Pathways in cancer pathway
Progesterone-mediated oocyte maturation pathway
Aldosterone-regulated sodium reabsorption pathway
Amoebiasis pathway
Bacterial invasion of epithelial cells pathway
Chagas disease (American trypanosomiasis) pathway
Osteoclast differentiation pathway
Toxoplasmosis pathway
Carbohydrate digestion and absorption pathway
Hepatitis C pathway
|
||||||||||||||||||||||
| INOH |
CD4 T cell receptor signaling pathway
IL-7 signaling pathway
B cell receptor signaling pathway
EPO signaling pathway pathway
FGF signaling pathway pathway
Insulin receptor signaling pathway
VEGF signaling pathway pathway
HGF signaling pathway pathway
IGF1 signaling pathway pathway
Inositol phosphate metabolism pathway
PDGF signaling pathway pathway
|
||||||||||||||||||||||
| PID NCI |
LPA receptor mediated events
|
||||||||||||||||||||||
| Cross-References | |||||||||||||||||||||||
| SwissProt | |||||||||||||||||||||||
| TrEMBL | D3Z2Z7 | ||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||
| Entrez Gene | 74769 | ||||||||||||||||||||||
| UniGene | Mm.213128 | ||||||||||||||||||||||
| RefSeq | NM_029094 XM_006511520 | ||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||
| CCDS | CCDS23432 | ||||||||||||||||||||||
| HPRD | |||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||
| MGI ID | MGI:1922019 | ||||||||||||||||||||||
| MGI Symbol | Pik3cb | ||||||||||||||||||||||
| EMBL | AC120148 AC122930 | ||||||||||||||||||||||
| GenPept | |||||||||||||||||||||||
| RNA Seq Atlas | 74769 | ||||||||||||||||||||||