InnateDB Protein
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IDBP-542807.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Tec
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Protein Name
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tec protein tyrosine kinase
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000120155
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InnateDB Gene
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IDBG-170167 (Tec)
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Protein Structure
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Function |
Non-receptor tyrosine kinase that contributes to signaling from many receptors and participates as a signal transducer in multiple downstream pathways, including regulation of the actin cytoskeleton. Plays a redundant role to ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. Required for TCR-dependent IL2 gene induction. Phosphorylates DOK1, one CD28-specific substrate, and contributes to CD28-signaling. Mediates signals that negatively regulate IL2RA expression induced by TCR cross-linking. Plays a redundant role to BTK in BCR-signaling for B-cell development and activation, especially by phosphorylating STAP1, a BCR-signaling protein. Required in mast cells for efficient cytokine production. Involved in both growth and differentiation mechanisms of myeloid cells through activation by the granulocyte colony-stimulating factor CSF3, a critical cytokine to promoting the growth, differentiation, and functional activation of myeloid cells. Participates in platelet signaling downstream of integrin activation. Cooperates with JAK2 through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. GRB10, a negative modifier of the FOS activation pathway, is another substrate of TEC. TEC is involved in G protein-coupled receptor- and integrin-mediated signalings in blood platelets. Plays a role in hepatocyte proliferation and liver regeneration and is involved in HGF-induced ERK signaling pathway. TEC regulates also FGF2 unconventional secretion (endoplasmic reticulum (ER)/Golgi-independent mechanism) under various physiological conditions through phosphorylation of FGF2 'Tyr-82'. May also be involved in the regulation of osteoclast differentiation. {ECO:0000269PubMed:10382746, ECO:0000269PubMed:15214045, ECO:0000269PubMed:19688741, ECO:0000269PubMed:21094130, ECO:0000269PubMed:9473212, ECO:0000269PubMed:9872994}.
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Subcellular Localization |
Cytoplasm. Cell membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton. Note=Following B-cell or T-cell receptors activation by antigen, translocates to the plasma membrane through its PH domain. Thrombin and integrin engagement induces translocation of TEC to the cytoskeleton during platelet activation. In cardiac myocytes, assumes a diffuse intracellular localization under basal conditions but is recruited to striated structures upon various stimuli, including ATP (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Preferentially expressed in liver. Expression is also seen in the hematopoietic cells such as bone marrow, thymus and spleen. Lower expression is seen in the heart, kidney and ovary.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.
Experimentally validated |
Total |
5
[view]
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Protein-Protein |
5
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
31 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:98662
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InterPro |
IPR001849
Pleckstrin homology domain
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PFAM |
PF00169
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PRINTS |
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PIRSF |
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SMART |
SM00233
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TIGRFAMs |
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Modification |
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SwissProt |
P24604
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PhosphoSite |
PhosphoSite-P24604
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
21682
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UniGene |
Mm.319581
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RefSeq |
NP_038717
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MGI ID |
1GL5
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MGI Symbol |
Tec
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
AF071936
AF071937
AF071938
AF071939
AF071940
AF071941
AF071942
AF071943
AF071944
AF071945
AF071946
M33427
S53716
X55663
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GenPept |
AAA13515
AAA40018
AAD43402
AAD43404
AAD43405
AAD43406
AAD43407
CAA39196
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