InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Tec

Summary

InnateDB Gene

IDBG-170167.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tec

Gene Name

tec protein tyrosine kinase

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000029217

Encoded Proteins

IDBP-170169

tec protein tyrosine kinase

IDBP-170171

tec protein tyrosine kinase

IDBP-253546

tec protein tyrosine kinase

IDBP-542528

tec protein tyrosine kinase

IDBP-542807

tec protein tyrosine kinase

IDBP-540456

tec protein tyrosine kinase

IDBP-532879

tec protein tyrosine kinase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000135605:
The protein encoded by this gene belongs to the Tec family of non-receptor protein-tyrosine kinases containing a pleckstrin homology domain. Tec family kinases are involved in the intracellular signaling mechanisms of cytokine receptors, lymphocyte surface antigens, heterotrimeric G-protein coupled receptors, and integrin molecules. They are also key players in the regulation of the immune functions. Tec kinase is an integral component of T cell signaling and has a distinct role in T cell activation. This gene may be associated with myelodysplastic syndrome. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:72755718-72868483

Strand

Reverse strand

Band

C3.2

Transcripts

ENSMUST00000073843	ENSMUSP00000073509
ENSMUST00000071944	ENSMUSP00000071836
ENSMUST00000113594	ENSMUSP00000109224
ENSMUST00000126481	ENSMUSP00000123606
ENSMUST00000138842	ENSMUSP00000120155
ENSMUST00000155342	ENSMUSP00000118980
ENSMUST00000149533	ENSMUSP00000123258
ENSMUST00000150193

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	31 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004715	non-membrane spanning protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008289	lipid binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0046872	metal ion binding

Biological Process

GO:0002376	immune system process
GO:0006468	protein phosphorylation
GO:0007229	integrin-mediated signaling pathway
GO:0010543	regulation of platelet activation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0035556	intracellular signal transduction
GO:0042246	tissue regeneration
GO:0050853	B cell receptor signaling pathway