InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ict1

Summary

InnateDB Protein

IDBP-542851.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ict1

Protein Name

immature colon carcinoma transcript 1

Synonyms

1110001A02Rik; 1110002E03Rik; MRP-L58;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000116746

InnateDB Gene

IDBG-214293 (Ict1)

Protein Structure

UniProt Annotation

Function

Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 234 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	234 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003747	translation release factor activity
GO:0004045	aminoacyl-tRNA hydrolase activity
GO:0016150	translation release factor activity, codon nonspecific