InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sumo2

Summary

InnateDB Protein

IDBP-542894.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sumo2

Protein Name

SMT3 suppressor of mif two 3 homolog 2 (yeast)

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000115044

InnateDB Gene

IDBG-214321 (Sumo2)

Protein Structure

UniProt Annotation

Function

Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Nucleus, PML body {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 1163 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1163 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019789	SUMO ligase activity
GO:0031625	ubiquitin protein ligase binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0016925	protein sumoylation
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter