InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Wnk2

Summary

InnateDB Protein

IDBP-542945.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Wnk2

Protein Name

WNK lysine deficient protein kinase 2

Synonyms

1810073P09Rik; AW122246; ESTM15; mKIAA1760; X83337;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000124614

InnateDB Gene

IDBG-150180 (Wnk2)

Protein Structure

UniProt Annotation

Function

Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5. Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression. Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1. WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity. {ECO:0000269PubMed:21733846}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}.

Disease Associations

Tissue Specificity

Brain and heart. {ECO:0000269PubMed:21733846}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0004674	protein serine/threonine kinase activity
GO:0005524	ATP binding

Biological Process

GO:0006468

protein phosphorylation

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

MGI:1922857

InterPro

PFAM

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q3UH66

PhosphoSite

PhosphoSite-Q3UH66

TrEMBL

UniProt Splice Variant

Entrez Gene

75607

UniGene

Mm.342723

RefSeq

MGI ID

MGI Symbol

Wnk2

OMIM

CCDS

HPRD

IMGT

EMBL

AC140284 AK044381 AK129439 AK147550 BC046464 BC055795 BC060187 CAAA01187366

GenPept

AAH46464 AAH55795 AAH60187 BAC98249 BAE20646 BAE27991