Version 5.4
Mus musculus Gene: Wnk2
Summary
InnateDB Gene IDBG-150180.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Wnk2
Gene Name WNK lysine deficient protein kinase 2
Synonyms 1810073P09Rik; AW122246; ESTM15; mKIAA1760; X83337
Species Mus musculus
Ensembl Gene ENSMUSG00000037989
Encoded Proteins
IDBP-150182
WNK lysine deficient protein kinase 2
IDBP-150184
WNK lysine deficient protein kinase 2
IDBP-150186
WNK lysine deficient protein kinase 2
IDBP-260993
WNK lysine deficient protein kinase 2
IDBP-260995
WNK lysine deficient protein kinase 2
IDBP-542940
WNK lysine deficient protein kinase 2
IDBP-542941
WNK lysine deficient protein kinase 2
IDBP-542943
WNK lysine deficient protein kinase 2
IDBP-542944
WNK lysine deficient protein kinase 2
IDBP-542945
WNK lysine deficient protein kinase 2
IDBP-542946
WNK lysine deficient protein kinase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000165238:
The protein encoded by this gene is a cytoplasmic serine-threonine kinase that contains cysteine in place of the lysine found at the conserved ATP-binding location in subdomain II of protein kinases. Since this protein does have kinase activity, it is possible that another lysine in the kinase subdomain I can substitute for the missing conserved lysine. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:49036303-49148014
Strand Reverse strand
Band A5
Transcripts
ENSMUST00000035538 ENSMUSP00000047231
ENSMUST00000049265 ENSMUSP00000049327
ENSMUST00000091623 ENSMUSP00000089212
ENSMUST00000110097 ENSMUSP00000105724
ENSMUST00000110096 ENSMUSP00000105723
ENSMUST00000162581 ENSMUSP00000125448
ENSMUST00000162403 ENSMUSP00000125539
ENSMUST00000159559 ENSMUSP00000123915
ENSMUST00000159196 ENSMUSP00000124598
ENSMUST00000160087 ENSMUSP00000124614
ENSMUST00000159633 ENSMUSP00000125522
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0006468 protein phosphorylation
GO:0008285 negative regulation of cell proliferation
GO:0046777 protein autophosphorylation
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:2000021 regulation of ion homeostasis
GO:2000651 positive regulation of sodium ion transmembrane transporter activity
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000165238
View Gene Order
ENSBTAG00000008301
Not yet available
Pathways
NETPATH
REACTOME
REACT_196640
Stimuli-sensing channels pathway
REACT_262350
Ion channel transport pathway
REACT_253400
Transmembrane transport of small molecules pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_160189
Stimuli-sensing channels pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_25300
Ion channel transport pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.342723
RefSeq NM_001290311 NM_001290313 NM_029361 XM_006516967 XM_006516968 XM_006516969 XM_006516970 XM_006516971 XM_006516972 XM_006516973 XM_006516974 XM_006516975 XM_006516976 XM_006516977 XM_006516978 XM_006516979
OMIM
CCDS CCDS70454 CCDS70455
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca