InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC36A1

Summary

InnateDB Protein

IDBP-54484.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC36A1

Protein Name

solute carrier family 36 (proton/amino acid symporter), member 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000243389

InnateDB Gene

IDBG-54482 (SLC36A1)

Protein Structure

UniProt Annotation

Function

Neutral amino acid/proton symporter. Has a pH-dependent electrogenic transport activity for small amino acids such as glycine, alanine and proline. Besides small apolar L-amino acids, it also recognize their D-enantiomers and selected amino acid derivatives such as gamma-aminobutyric acid (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Lysosome membrane {ECO:0000269PubMed:17897319}; Multi-pass membrane protein {ECO:0000269PubMed:17897319}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0015078	hydrogen ion transmembrane transporter activity
GO:0015180	L-alanine transmembrane transporter activity
GO:0015187	glycine transmembrane transporter activity
GO:0015193	L-proline transmembrane transporter activity
GO:0015293	symporter activity

Biological Process

GO:0006811	ion transport
GO:0006865	amino acid transport
GO:0015804	neutral amino acid transport
GO:0015808	L-alanine transport
GO:0015816	glycine transport
GO:0015824	proline transport
GO:0015992	proton transport
GO:0035524	proline transmembrane transport
GO:0055085	transmembrane transport
GO:1902600	hydrogen ion transmembrane transport