InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RASGRP2

Summary

InnateDB Protein

IDBP-54506.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RASGRP2

Protein Name

RAS guanyl releasing protein 2 (calcium and DAG-regulated)

Synonyms

CALDAG-GEFI; CDC25L;

Species

Homo sapiens

Ensembl Protein

ENSP00000366717

InnateDB Gene

IDBG-54498 (RASGRP2)

Protein Structure

UniProt Annotation

Function

Functions as a calcium- and DAG-regulated nucleotide exchange factor specifically activating Rap through the exchange of bound GDP for GTP. May also activates other GTPases such as RRAS, RRAS2, NRAS, KRAS but not HRAS. Functions in aggregation of platelets and adhesion of T-lymphocytes and neutrophils probably through inside-out integrin activation. May function in the muscarinic acetylcholine receptor M1/CHRM1 signaling pathway. {ECO:0000269PubMed:10918068, ECO:0000269PubMed:14702343, ECO:0000269PubMed:17576779, ECO:0000269PubMed:17702895}.

Subcellular Localization

Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Cell junction, synapse, synaptosome {ECO:0000305}. Cell projection, ruffle membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Note=Found both in the cytosol and associated with membranes. Isoform 2 mainly localizes to the cell membrane. Enriched at juxtamembrane areas and membrane ruffles through association with F-actin. Localizes to the cell bodies and axons of striatal neurons (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Detected in platelets, neutrophils and T lymphocytes (at protein level). Expressed in brain where it is enriched in the striatum. Also expressed in the hematopoietic system. Detected in heart, brain, lung, placenta, liver, skeletal muscle and kidney. {ECO:0000269PubMed:10918068, ECO:0000269PubMed:17576779, ECO:0000269PubMed:17702895, ECO:0000269PubMed:9341881, ECO:0000269PubMed:9789079}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	3 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005509	calcium ion binding
GO:0008289	lipid binding
GO:0019992	diacylglycerol binding

Biological Process

GO:0001558	regulation of cell growth
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0007265	Ras protein signal transduction
GO:0007596	blood coagulation
GO:0030168	platelet activation
GO:0035556	intracellular signal transduction
GO:0043547	positive regulation of GTPase activity
GO:0051056	regulation of small GTPase mediated signal transduction

Cellular Component

GO:0005622	intracellular
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0030054	cell junction
GO:0032587	ruffle membrane
GO:0043005	neuron projection
GO:0045202	synapse

Protein Structure and Domains

PDB ID

InterPro

IPR000651 Ras-like guanine nucleotide exchange factor, N-terminal
IPR001895 Ras guanine-nucleotide exchange factors catalytic domain
IPR002048 EF-hand domain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
IPR023578 Ras guanine nucleotide exchange factor domain

PFAM

PF00618
PF00617
PF00036
PF13202
PF13405
PF00130

PRINTS

PIRSF

SMART

SM00229
SM00147
SM00054
SM00109

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q7LDG7