InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SPARC

Summary

InnateDB Protein

IDBP-54564.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SPARC

Protein Name

secreted protein, acidic, cysteine-rich (osteonectin)

Synonyms

ON;

Species

Homo sapiens

Ensembl Protein

ENSP00000231061

InnateDB Gene

IDBG-54562 (SPARC)

Protein Structure

UniProt Annotation

Function

Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.

Subcellular Localization

Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000269PubMed:2306517, ECO:0000269PubMed:3400777, ECO:0000269PubMed:7495300, ECO:0000269PubMed:9457905}. Note=In or around the basement membrane.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	25 [view]
Protein-Protein	24 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005518	collagen binding
GO:0050840	extracellular matrix binding

Biological Process

GO:0001503	ossification
GO:0002576	platelet degranulation
GO:0007165	signal transduction
GO:0007507	heart development
GO:0007596	blood coagulation
GO:0009629	response to gravity
GO:0010288	response to lead ion
GO:0030168	platelet activation
GO:0030198	extracellular matrix organization
GO:0030324	lung development
GO:0032496	response to lipopolysaccharide
GO:0033591	response to L-ascorbic acid
GO:0034097	response to cytokine
GO:0042060	wound healing
GO:0042127	regulation of cell proliferation
GO:0043434	response to peptide hormone
GO:0045471	response to ethanol
GO:0046686	response to cadmium ion
GO:0048839	inner ear development
GO:0051384	response to glucocorticoid
GO:0051591	response to cAMP
GO:0051592	response to calcium ion
GO:0060348	bone development
GO:0071363	cellular response to growth factor stimulus

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005604	basement membrane
GO:0005615	extracellular space
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0031012	extracellular matrix
GO:0031093	platelet alpha granule lumen
GO:0031988	membrane-bounded vesicle
GO:0071682	endocytic vesicle lumen

Protein Structure and Domains

PDB ID

InterPro

IPR002350 Kazal domain
IPR003645 Follistatin-like, N-terminal
IPR015369 Follistatin/Osteonectin EGF domain
IPR019577 SPARC/Testican, calcium-binding domain

PFAM

PF00050
PF07648
PF09289
PF10591

PRINTS

PIRSF

SMART

SM00280
SM00274

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P09486