InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: G3BP1

Summary

InnateDB Protein

IDBP-54621.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

G3BP1

Protein Name

GTPase activating protein (SH3 domain) binding protein 1

Synonyms

G3BP; HDH-VIII;

Species

Homo sapiens

Ensembl Protein

ENSP00000348578

InnateDB Gene

IDBG-54619 (G3BP1)

Protein Structure

UniProt Annotation

Function

May be a regulated effector of stress granule assembly. Phosphorylation-dependent sequence-specific endoribonuclease in vitro. Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR. ATP- and magnesium- dependent helicase. Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends. Unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency. Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA. {ECO:0000269PubMed:11604510, ECO:0000269PubMed:9889278}.

Subcellular Localization

Cytoplasm. Cytoplasm, cytosol. Cytoplasmic granule. Cell membrane. Nucleus. Note=Cytoplasmic in proliferating cells, can be recruited to the plasma membrane in exponentially growing cells (By similarity). Cytosolic and partially nuclear in resting cells. Recruited to stress granules (SGs) upon either arsenite or high temperature treatment. Recruitment to SGs is influenced by HRAS. {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 116 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	116 [view]
Protein-Protein	114 [view]
Protein-DNA	1 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0004003	ATP-dependent DNA helicase activity
GO:0004004	ATP-dependent RNA helicase activity
GO:0004519	endonuclease activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006200	ATP catabolic process
GO:0006810	transport
GO:0007265	Ras protein signal transduction
GO:0032508	DNA duplex unwinding
GO:0045087	innate immune response (InnateDB)
GO:0090305	nucleic acid phosphodiester bond hydrolysis