InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CDKN2B

Summary

InnateDB Protein

IDBP-54660.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CDKN2B

Protein Name

cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)

Synonyms

CDK4I; INK4B; MTS2; P15; p15INK4b; TP15;

Species

Homo sapiens

Ensembl Protein

ENSP00000276925

InnateDB Gene

IDBG-54658 (CDKN2B)

Protein Structure

UniProt Annotation

Function

Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:9230210}. Note=Also found in the nucleus.

Disease Associations

Tissue Specificity

Isoform 2 is expressed in normal (keratinocytes, fibroblasts) and tumor cell lines. {ECO:0000269PubMed:9230210}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	22 [view]
Protein-Protein	17 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity
GO:0005515	protein binding
GO:0019901	protein kinase binding

Biological Process

GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000086	G2/M transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0001889	liver development
GO:0006351	transcription, DNA-templated
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0007050	cell cycle arrest
GO:0007093	mitotic cell cycle checkpoint
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007568	aging
GO:0008285	negative regulation of cell proliferation
GO:0010467	gene expression
GO:0014070	response to organic cyclic compound
GO:0030219	megakaryocyte differentiation
GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway
GO:0030858	positive regulation of epithelial cell differentiation
GO:0031668	cellular response to extracellular stimulus
GO:0031670	cellular response to nutrient
GO:0034097	response to cytokine
GO:0042326	negative regulation of phosphorylation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048536	spleen development
GO:0050680	negative regulation of epithelial cell proliferation
GO:0071901	negative regulation of protein serine/threonine kinase activity
GO:2000134	negative regulation of G1/S transition of mitotic cell cycle