InnateDB Protein
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IDBP-54662.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CDKN2B
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Protein Name
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cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
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Synonyms
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CDK4I; INK4B; MTS2; P15; p15INK4b; TP15;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000369487
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InnateDB Gene
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IDBG-54658 (CDKN2B)
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Protein Structure
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Function |
Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:9230210}. Note=Also found in the nucleus.
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Disease Associations |
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Tissue Specificity |
Isoform 2 is expressed in normal (keratinocytes, fibroblasts) and tumor cell lines. {ECO:0000269PubMed:9230210}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated |
Total |
22
[view]
|
Protein-Protein |
17
[view]
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Protein-DNA |
5
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
4 [view]
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Molecular Function |
Accession |
GO Term |
GO:0004861
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cyclin-dependent protein serine/threonine kinase inhibitor activity
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GO:0005515
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protein binding
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GO:0019901
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protein kinase binding
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Biological Process |
GO:0000079
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regulation of cyclin-dependent protein serine/threonine kinase activity
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GO:0000086
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G2/M transition of mitotic cell cycle
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GO:0000278
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mitotic cell cycle
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GO:0006351
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transcription, DNA-templated
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GO:0006367
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transcription initiation from RNA polymerase II promoter
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GO:0007050
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cell cycle arrest
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GO:0007093
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mitotic cell cycle checkpoint
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GO:0007179
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transforming growth factor beta receptor signaling pathway
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GO:0008285
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negative regulation of cell proliferation
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GO:0010467
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gene expression
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GO:0030219
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megakaryocyte differentiation
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GO:0030511
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positive regulation of transforming growth factor beta receptor signaling pathway
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GO:0031668
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cellular response to extracellular stimulus
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GO:0031670
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cellular response to nutrient
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GO:0042326
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negative regulation of phosphorylation
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GO:0045944
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positive regulation of transcription from RNA polymerase II promoter
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GO:0050680
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negative regulation of epithelial cell proliferation
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GO:0071901
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negative regulation of protein serine/threonine kinase activity
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Cellular Component |
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PDB ID |
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InterPro |
IPR020683
Ankyrin repeat-containing domain
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PFAM |
PF11929
PF12796
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PRINTS |
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PIRSF |
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SMART |
|
TIGRFAMs |
|
Modification |
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SwissProt |
P42772
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PhosphoSite |
PhosphoSite-
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TrEMBL |
Q9UM95
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UniProt Splice Variant |
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Entrez Gene |
1030
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UniGene |
|
RefSeq |
NP_511042
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HUGO |
HGNC:1788
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OMIM |
600431
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CCDS |
CCDS6513
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HPRD |
02696
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IMGT |
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EMBL |
AF004819
AF513858
AL449423
BC014469
CR536529
L36844
S69805
S75756
U17075
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GenPept |
AAA50282
AAB69989
AAC50075
AAD14049
AAD14186
AAH14469
AAM44859
CAG38766
CAH70602
CAH70603
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