InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BMP10

Summary

InnateDB Protein

IDBP-54665.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BMP10

Protein Name

bone morphogenetic protein 10

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000295379

InnateDB Gene

IDBG-54663 (BMP10)

Protein Structure

UniProt Annotation

Function

Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines. {ECO:0000269PubMed:16049014, ECO:0000269PubMed:17068149, ECO:0000269PubMed:20608934}.

Subcellular Localization

Secreted {ECO:0000250}.

Disease Associations

Tissue Specificity

Detected in mammary epithelia (at protein level). {ECO:0000269PubMed:20608934}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005179	hormone activity
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0033612	receptor serine/threonine kinase binding

Biological Process

GO:0007155	cell adhesion
GO:0007507	heart development
GO:0007512	adult heart development
GO:0010596	negative regulation of endothelial cell migration
GO:0010613	positive regulation of cardiac muscle hypertrophy
GO:0010614	negative regulation of cardiac muscle hypertrophy
GO:0010628	positive regulation of gene expression
GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0014898	cardiac muscle hypertrophy in response to stress
GO:0030198	extracellular matrix organization
GO:0030308	negative regulation of cell growth
GO:0030336	negative regulation of cell migration
GO:0030509	BMP signaling pathway
GO:0032924	activin receptor signaling pathway
GO:0040007	growth
GO:0045214	sarcomere organization
GO:0045893	positive regulation of transcription, DNA-templated
GO:0055009	atrial cardiac muscle tissue morphogenesis
GO:0055010	ventricular cardiac muscle tissue morphogenesis
GO:0055015	ventricular cardiac muscle cell development
GO:0055117	regulation of cardiac muscle contraction
GO:0060038	cardiac muscle cell proliferation
GO:0060045	positive regulation of cardiac muscle cell proliferation
GO:0060298	positive regulation of sarcomere organization
GO:0060347	heart trabecula formation
GO:0060389	pathway-restricted SMAD protein phosphorylation
GO:2000138	positive regulation of cell proliferation involved in heart morphogenesis

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0009986	cell surface
GO:0030018	Z disc

Protein Structure and Domains

PDB ID

InterPro

IPR001111 Transforming growth factor-beta, N-terminal
IPR001839 Transforming growth factor-beta, C-terminal
IPR002405 Inhibin, alpha subunit
IPR029034 Cystine-knot cytokine

PFAM

PF00688
PF00019

PRINTS

PR00669

PIRSF

SMART

SM00204

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt