InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RFX4

Summary

InnateDB Protein

IDBP-54858.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RFX4

Protein Name

regulatory factor X, 4 (influences HLA class II expression)

Synonyms

NYD-SP10;

Species

Homo sapiens

Ensembl Protein

ENSP00000350552

InnateDB Gene

IDBG-54856 (RFX4)

Protein Structure

UniProt Annotation

Function

May activate transcription by interacting directly with the X-box. {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00858}.

Disease Associations

Tissue Specificity

Isoform 4 is testis-specific. Isoform 1 is expressed in brain and gliomas. Isoform 2 and isoform 3 are testis-specific (at protein level). Isoform 1 is expressed in brain (at protein level). Isoform 3 is expressed at a higher level in adult testes and ejaculated spematozoa than in fetal testes. {ECO:0000269PubMed:11682486, ECO:0000269PubMed:16193984, ECO:0000269PubMed:16271074}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0005515	protein binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0021516	dorsal spinal cord development
GO:0021537	telencephalon development
GO:0021696	cerebellar cortex morphogenesis
GO:0021914	negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning
GO:0030900	forebrain development
GO:0030901	midbrain development
GO:0042384	cilium assembly
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0070613	regulation of protein processing