Version 5.4
Homo sapiens Protein: RFX4
Summary
InnateDB Protein IDBP-54862.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RFX4
Protein Name regulatory factor X, 4 (influences HLA class II expression)
Synonyms NYD-SP10;
Species Homo sapiens
Ensembl Protein ENSP00000229387
InnateDB Gene IDBG-54856 (RFX4)
Protein Structure
UniProt Annotation
Function May activate transcription by interacting directly with the X-box. {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000255PROSITE- ProRule:PRU00858}.
Disease Associations
Tissue Specificity Isoform 4 is testis-specific. Isoform 1 is expressed in brain and gliomas. Isoform 2 and isoform 3 are testis-specific (at protein level). Isoform 1 is expressed in brain (at protein level). Isoform 3 is expressed at a higher level in adult testes and ejaculated spematozoa than in fetal testes. {ECO:0000269PubMed:11682486, ECO:0000269PubMed:16193984, ECO:0000269PubMed:16271074}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
Biological Process
GO:0006351 transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q33E94
PhosphoSite PhosphoSite-Q33E94
TrEMBL R4GMS3
UniProt Splice Variant
Entrez Gene 5992
UniGene Hs.388827
RefSeq NP_115880
HUGO HGNC:9985
OMIM 603958
CCDS CCDS9108
HPRD 04905
IMGT
EMBL AB044245 AB095365 AB095366 AB195784 AB195785 AC009721 AC079385 AF332192 AK074913 AK291445 AK315698 AL833921 AY102009 BC028582 BC030644 CH471054
GenPept AAH28582 AAH30644 AAK17191 AAM52484 BAB59001 BAC11288 BAE48231 BAE48232 BAE48237 BAE48238 BAF84134 BAG38061 CAD38777 EAW97782 EAW97783 EAW97784

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca