InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SF1

Summary

InnateDB Protein

IDBP-54911.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SF1

Protein Name

splicing factor 1

Synonyms

BBP; D11S636; MBBP; ZCCHC25; ZFM1; ZNF162;

Species

Homo sapiens

Ensembl Protein

ENSP00000366604

InnateDB Gene

IDBG-54901 (SF1)

Protein Structure

UniProt Annotation

Function

Necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. May act as transcription repressor. {ECO:0000269PubMed:10449420, ECO:0000269PubMed:8752089, ECO:0000269PubMed:9660765}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Detected in lung, ovary, adrenal gland, colon, kidney, muscle, pancreas, thyroid, placenta, brain, liver and heart. {ECO:0000269PubMed:7912130}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 121 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	121 [view]
Protein-Protein	120 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003714	transcription corepressor activity
GO:0003723	RNA binding
GO:0008270	zinc ion binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000245	spliceosomal complex assembly
GO:0000389	mRNA 3'-splice site recognition
GO:0000398	mRNA splicing, via spliceosome
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0030238	male sex determination
GO:0033327	Leydig cell differentiation
GO:0048662	negative regulation of smooth muscle cell proliferation
GO:0050810	regulation of steroid biosynthetic process