InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SF1

Summary

InnateDB Gene

IDBG-54901.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SF1

Gene Name

splicing factor 1

Synonyms

BBP; D11S636; MBBP; ZCCHC25; ZFM1; ZNF162

Species

Homo sapiens

Ensembl Gene

ENSG00000168066

Encoded Proteins

IDBP-54903

splicing factor 1

IDBP-54905

splicing factor 1

IDBP-54907

splicing factor 1

IDBP-54909

splicing factor 1

IDBP-54911

splicing factor 1

IDBP-377737

splicing factor 1

IDBP-377741

splicing factor 1

IDBP-377743

splicing factor 1

IDBP-377744

splicing factor 1

IDBP-377746

splicing factor 1

IDBP-377747

splicing factor 1

IDBP-473650

splicing factor 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a nuclear pre-mRNA splicing factor. The encoded protein specifically recognizes the intron branch point sequence and is required for the early stages of spliceosome assembly. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:64764606-64778786

Strand

Reverse strand

Band

q13.1

Transcripts

ENST00000334944	ENSP00000334414
ENST00000377394	ENSP00000366611
ENST00000227503	ENSP00000227503
ENST00000377390	ENSP00000366607
ENST00000377387	ENSP00000366604
ENST00000448404	ENSP00000407962
ENST00000443908	ENSP00000391198
ENST00000413725	ENSP00000395927
ENST00000433274	ENSP00000396793
ENST00000413951	ENSP00000388470
ENST00000432725	ENSP00000406354
ENST00000486867	ENSP00000419062
ENST00000477596
ENST00000489544
ENST00000486960
ENST00000496969
ENST00000482693
ENST00000463343
ENST00000472725

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 121 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	121 [view]
Protein-Protein	120 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003714	transcription corepressor activity
GO:0003723	RNA binding
GO:0008270	zinc ion binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000245	spliceosomal complex assembly
GO:0000389	mRNA 3'-splice site recognition
GO:0000398	mRNA splicing, via spliceosome
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0030238	male sex determination
GO:0033327	Leydig cell differentiation
GO:0048662	negative regulation of smooth muscle cell proliferation
GO:0050810	regulation of steroid biosynthetic process

Cellular Component

GO:0005634	nucleus
GO:0005681	spliceosomal complex
GO:0005840	ribosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000024949

View Gene Order

ENSBTAG00000001035

Not yet available

Pathways

NETPATH

NetPath_2

AndrogenReceptor pathway

REACTOME

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.502829 Hs.613898

RefSeq

NM_001178030 NM_001178031 NM_004630 NM_201995 NM_201997 NM_201998 XM_006718681 XM_006718682 XM_006718683 XM_006718684 XM_006718685

HUGO

OMIM

CCDS

CCDS31599 CCDS44642 CCDS53660 CCDS53661 CCDS8080 CCDS8081

HPRD

03306

IMGT

EMBL

GenPept

RNA Seq Atlas