InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ARHGAP27

Summary

InnateDB Protein

IDBP-54928.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARHGAP27

Protein Name

Rho GTPase activating protein 27

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000290470

InnateDB Gene

IDBG-54926 (ARHGAP27)

Protein Structure

UniProt Annotation

Function

Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1 (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in germinal center B-cell, spleen, chronic lymphocytic leukemia, pancreatic cancer and lung cancer. {ECO:0000269PubMed:15492870}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0017124	SH3 domain binding
GO:0030675	Rac GTPase activator activity

Biological Process

GO:0006898	receptor-mediated endocytosis
GO:0007165	signal transduction
GO:0032855	positive regulation of Rac GTPase activity
GO:0043089	positive regulation of Cdc42 GTPase activity