Version 5.4
Homo sapiens Gene: ARHGAP27
Summary
InnateDB Gene IDBG-54926.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARHGAP27
Gene Name Rho GTPase activating protein 27
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000159314
Encoded Proteins
IDBP-54867
Rho GTPase activating protein 27
IDBP-54928
Rho GTPase activating protein 27
IDBP-379976
Rho GTPase activating protein 27
IDBP-593036
Rho GTPase activating protein 27
IDBP-584742
Rho GTPase activating protein 27
IDBP-600753
Rho GTPase activating protein 27
IDBP-596261
Rho GTPase activating protein 27
IDBP-585814
Rho GTPase activating protein 27
IDBP-590014
Rho GTPase activating protein 27
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Rho (see ARHA; MIM 165390)-like small GTPases are involved in many cellular processes, and they are inactive in the GDP-bound state and active in the GTP-bound state. GTPase-activating proteins, such as ARHGAP27, inhibit Rho-like proteins by stimulating their intrinsic GTPase activity (Katoh and Katoh, 2004 [PubMed 15492870]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:45393902-45434421
Strand Reverse strand
Band q21.31
Transcripts
ENST00000376922 ENSP00000366121
ENST00000290470 ENSP00000290470
ENST00000428638 ENSP00000403323
ENST00000532038 ENSP00000432762
ENST00000531735
ENST00000528384 ENSP00000431591
ENST00000532891 ENSP00000433942
ENST00000529357
ENST00000526484
ENST00000524404 ENSP00000431722
ENST00000532667
ENST00000528677 ENSP00000437100
ENST00000527678
ENST00000528273 ENSP00000436137
ENST00000581638
ENST00000579357
ENST00000590026
ENST00000582826
ENST00000581991
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005096 GTPase activator activity
GO:0005515 protein binding
GO:0017124 SH3 domain binding
GO:0030675 Rac GTPase activator activity
Biological Process
GO:0006898 receptor-mediated endocytosis
GO:0007165 signal transduction
GO:0032855 positive regulation of Rac GTPase activity
GO:0043089 positive regulation of Cdc42 GTPase activity
GO:0043547 positive regulation of GTPase activity
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000034255
View Gene Order
ENSBTAG00000000571
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001282290 NM_174919 NM_199282 XM_005257127 XM_005257128 XM_005275642 XM_006721745 XM_006721746 XM_006721747 XM_006725261 XM_006725608 XM_006725609 XM_006725610 XM_006725612 XM_006725613
HUGO
OMIM
CCDS CCDS11498 CCDS32670 CCDS74082
HPRD 12477
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca